用于将异烟肼高效递送至分枝杆菌的海藻糖共轭光功能化介孔二氧化硅纳米颗粒
Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria.
作者信息
Zhou Juan, Jayawardana Kalana W, Kong Na, Ren Yansong, Hao Nanjing, Yan Mingdi, Ramström Olof
机构信息
Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 30, S-10044 Stockholm, Sweden.
Department of Chemistry, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts 01854, United States.
出版信息
ACS Biomater Sci Eng. 2015 Dec 14;1(12):1250-1255. doi: 10.1021/acsbiomaterials.5b00274. Epub 2015 Nov 11.
Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with -trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.
糖纳米颗粒载体已被合成并有效地递送至分枝杆菌中。介孔二氧化硅纳米颗粒通过叠氮介导的表面光连接用海藻糖进行功能化，并负载抗结核药物异烟肼。糖纳米颗粒显示出高异烟肼负载能力，且比游离药物具有更高的抗菌活性。
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