State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry , Fuzhou University , Fuzhou 350116 , P. R. China.
State Key Laboratory of Structural Chemistry , Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou , Fujian 350002 , P. R. China.
Org Lett. 2018 Oct 5;20(19):6012-6016. doi: 10.1021/acs.orglett.8b02300. Epub 2018 Sep 27.
An efficient carbene organocatalyzed route to enantioenriched chromenones, bearing one tri- or difluoromethylated stereogenic center in the β position of the carbonyl group, from o-allyloxybenzaldehydes is described. The one-pot transition-metal-free transformation exhibits a broad substrate scope and excellent enantioselectivity.
描述了一种高效的卡宾有机催化途径，用于从邻烯丙氧基苯甲醛合成对映体富集的色烯酮，其中羰基的β位带有一个三氟甲基或二氟甲基手性中心。该一锅无过渡金属转化具有广泛的底物范围和优异的对映选择性。
