适用于各种场合的帽结构：替代性eIF4F复合物
A Cap for Every Occasion: Alternative eIF4F Complexes.
作者信息
Ho J J David, Lee Stephen
机构信息
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA.
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA.
出版信息
Trends Biochem Sci. 2016 Oct;41(10):821-823. doi: 10.1016/j.tibs.2016.05.009. Epub 2016 Jun 6.
Abstract
The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5' cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.
摘要
真核生物翻译起始因子4F（eIF4F）在本质上已成为5'帽依赖性mRNA翻译的代名词。最近的研究表明，在抑制eIF4F的生理条件下，细胞会组装eIF4F变体以产生适应性的、帽依赖性翻译组。这些发现促使我们重新评估对细胞翻译途径的传统认知。
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