Semenov V M
Vopr Virusol. 1989 Jan-Feb;34(1):77-81.
Humoral and cell-mediated immune response to antigens of hepatitis B (HBsAg and HBeAg), delta-virus, rubella, and measles viruses was studied. Detection in a number of patients with rheumatoid arthritis of HBsAg and HBeAg in blood sera permits a conclusion that productive virus infection is formed in such patients. At the same time in patients with rheumatoid arthritis areactivity of immunocytes to HBsAg and HBeAg was found while marked sensitization of lymphocytes to rubella virus antigens was demonstrated. The patients with rheumatoid arthritis, however, do not develop mere long-term carrier state of hepatitis B virus but form primary chronic hepatitis as a consequence of virus infection. This is indicated by an increase in the level of alanine aminotransferase (1.6 +/- 0.8 mmol/l) and detection of antibody to delta-virus in such patients (28.6%).
研究了对乙型肝炎抗原（HBsAg和HBeAg）、丁型病毒、风疹病毒和麻疹病毒的体液免疫和细胞介导免疫反应。在一些类风湿性关节炎患者的血清中检测到HBsAg和HBeAg，这使得可以得出结论，这些患者形成了有病毒复制的感染。同时，在类风湿性关节炎患者中发现免疫细胞对HBsAg和HBeAg有反应性，而淋巴细胞对风疹病毒抗原表现出明显的致敏性。然而，类风湿性关节炎患者并非仅仅形成乙型肝炎病毒的长期携带状态，而是由于病毒感染形成了原发性慢性肝炎。这表现为丙氨酸转氨酶水平升高（1.6±0.8 mmol/l），并且在这些患者中检测到丁型病毒抗体（28.6%）。
