Shirodaria P V, Haire M, Fleming E, Merrett J D, Hawkins S A, Roberts S D
Queen's University of Belfast.
Arch Neurol. 1987 Dec;44(12):1237-41. doi: 10.1001/archneur.1987.00520240019006.
Higher titers of antibodies to measles virus envelope antigens, hemolysin and hemagglutinin, Epstein-Barr virus (EBV) capsid antigen and nuclear antigen, and rubella virus hemagglutinin were demonstrated in serum samples of patients with multiple sclerosis and rheumatoid arthritis than in age- and sex-matched control subjects. A significant correlation was observed between antibodies to measles and rubella viruses both in patients with multiple sclerosis and rheumatoid arthritis, but such a correlation was not observed between antibodies to EBV and measles or rubella viruses. Whether elevated levels of antibodies to EBV are due to reactivation of the virus, or elevated levels of antibodies to all the enveloped viruses result from cross-reactions between viruses and host tissue, or perhaps reflect defects in immunoregulation, needs further investigation.
与年龄和性别匹配的对照受试者相比，在多发性硬化症和类风湿性关节炎患者的血清样本中，检测到针对麻疹病毒包膜抗原、溶血素和血凝素、爱泼斯坦-巴尔病毒（EBV）衣壳抗原和核抗原以及风疹病毒血凝素的抗体滴度更高。在多发性硬化症和类风湿性关节炎患者中，均观察到针对麻疹病毒和风疹病毒的抗体之间存在显著相关性，但在针对EBV与麻疹或风疹病毒的抗体之间未观察到这种相关性。EBV抗体水平升高是由于病毒再激活，还是所有包膜病毒的抗体水平升高是由于病毒与宿主组织之间的交叉反应，或者可能反映了免疫调节缺陷，尚需进一步研究。
