8岁以下儿童产前多溴联苯醚暴露与体重指数
Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age.
作者信息
Vuong Ann M, Braun Joseph M, Sjödin Andreas, Webster Glenys M, Yolton Kimberly, Lanphear Bruce P, Chen Aimin
机构信息
Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
出版信息
Environ Health Perspect. 2016 Dec;124(12):1891-1897. doi: 10.1289/EHP139. Epub 2016 Jun 10.
BACKGROUND
Prenatal exposure to endocrine disruptors has been associated with increased risk of childhood obesity. However, epidemiologic studies on polybrominated diphenyl ethers (PBDEs) are limited despite animal studies indicating PBDEs' potential role as an obesogen.
OBJECTIVES
We investigated whether maternal concentrations of BDEs 28, 47, 99, 100, 153, and ΣPBDEs during pregnancy were associated with anthropometric measures in children aged 1-8 years.
METHODS
We examined 318 mother-child pairs in the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort enrolled from 2003 through 2006 (Cincinnati, OH). Serum PBDEs were measured at 16 ± 3 weeks gestation. We measured child height (1-8 years), weight (1-8 years), body mass index (BMI) (2-8 years), waist circumference (4-8 years), and body fat (8 years). To account for repeated measures, we used linear mixed models and generalized estimating equations to estimate associations between maternal PBDEs and child anthropometric measures.
RESULTS
We found no statistically significant associations between prenatal PBDEs and height or weight z-score. A 10-fold increase in maternal serum BDE-153 was associated with lower BMI z-score (β = -0.36; 95% CI: -0.60, -0.13) at 2-8 years, smaller waist circumference (β = -1.81 cm; 95% CI: -3.13, -0.50) at 4-8 years, and lower percent body fat (β = -2.37%; 95% CI: -4.21, -0.53) at 8 years. A decrease in waist circumference at 4-8 years was observed with a 10-fold increase in BDE-100 (β = -1.50 cm; 95% CI: -2.93, -0.08) and ΣPBDEs (β = -1.57 cm; 95% CI: -3.11, -0.02).
CONCLUSIONS
Reverse causality may have resulted in prenatal PBDEs, particularly BDE-153, and decreased BMI, waist circumference, and body fat. Citation: Vuong AM, Braun JM, Sjödin A, Webster GM, Yolton K, Lanphear BP, Chen A. 2016. Prenatal polybrominated diphenyl ether exposure and body mass index in children up to 8 years of age. Environ Health Perspect 124:1891-1897; http://dx.doi.org/10.1289/EHP139.
背景
孕期暴露于内分泌干扰物与儿童肥胖风险增加有关。然而，尽管动物研究表明多溴二苯醚（PBDEs）可能具有致肥胖作用，但关于多溴二苯醚的流行病学研究仍然有限。
目的
我们调查了孕期母亲血清中BDE - 28、47、99、100、153及ΣPBDEs的浓度与1 - 8岁儿童人体测量指标之间的关系。
方法
我们在“健康结果与环境测量”（HOME）研究中对318对母婴进行了调查，该出生队列于2003年至2006年在俄亥俄州辛辛那提招募。在妊娠16±3周时测量母亲血清中的PBDEs。我们测量了儿童的身高（1 - 8岁）、体重（1 - 8岁）、体重指数（BMI）（2 - 8岁）、腰围（4 - 8岁）和体脂（8岁）。为了考虑重复测量因素，我们使用线性混合模型和广义估计方程来估计母亲PBDEs水平与儿童人体测量指标之间的关联。
结果
我们发现产前PBDEs与身高或体重z评分之间无统计学显著关联。母亲血清中BDE - 153增加10倍与2 - 8岁时较低的BMI z评分（β = -0.36；95%可信区间：-0.60，-0.13）、4 - 8岁时较小的腰围（β = -1.81厘米；95%可信区间：-3.13，-0.50）以及8岁时较低的体脂百分比（β = -2.37%；95%可信区间：-4.21，-0.53）相关。BDE - 100和ΣPBDEs增加10倍时，观察到4 - 8岁时腰围减小（BDE - 100：β = -1.50厘米；95%可信区间：-2.93，-0.08；ΣPBDEs：β = -1.57厘米；95%可信区间：-3.11，-0.02）。
结论
反向因果关系可能导致产前PBDEs，特别是BDE - 153与BMI、腰围和体脂降低有关。引文：Vuong AM，Braun JM，Sjödin A，Webster GM，Yolton K，Lanphear BP，Chen A. 2016. 产前多溴二苯醚暴露与8岁以下儿童体重指数。《环境健康展望》124：1891 - 1897；http://dx.doi.org/10.1289/EHP139 。
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