产前多溴联苯醚暴露与 5 至 14 岁儿童 BMI Z 评分的关系
Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years.
机构信息
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St. Room 1105, New York, NY, 10032, USA.
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
Environ Health. 2022 Sep 8;21(1):82. doi: 10.1186/s12940-022-00893-5.
BACKGROUND
Polybrominated diphenyl ethers (PBDEs) are flame-retardant compounds widely used in household products until phase out in 2004. PBDEs are endocrine disruptors and are suggested to influence signaling related to weight control. Prenatal exposures to PBDEs may alter childhood adiposity, yet few studies have examined these associations in human populations.
METHODS
Data were collected from a birth cohort of Dominican and African American mother-child pairs from New York City recruited from 1998 to 2006. PBDE congeners BDE-47, - 99, - 100, and - 153 were measured in cord plasma (ng/μL) and dichotomized into low (< 80th percentile) and high (>80th percentile) exposure categories. Height and weight were collected at ages 5, 7, 9, 11, and an ancillary visit from 8 to 14 years (n = 289). Mixed-effects models with random intercepts for participant were used to assess associations between concentrations of individual PBDE congeners or the PBDE sum and child BMI z-scores (BMIz). To assess associations between PBDEs and the change in BMIz over time, models including interactions between PBDE categories and child age and (child age) were fit. Quantile g-computation was used to investigate associations between BMIz and the total PBDE mixture. Models were adjusted for baseline maternal covariates: ethnicity, age, education, parity, partnership status, and receipt of public assistance, and child covariates: child sex and cord cholesterol and triglycerides.
RESULTS
The prevalence of children with obesity at age 5 was 24.2% and increased to 30% at age 11. Neither cord levels of individual PBDEs nor the total PBDE mixture were associated with overall BMIz in childhood. The changes in BMIz across childhood were not different between children with low or high PBDEs. Results were similar when adjusting for postnatal PBDE exposures.
CONCLUSIONS
Prenatal PBDE exposures were not associated with child growth trajectories in a cohort of Dominican and African American children.
背景
多溴联苯醚 (PBDEs) 是一种广泛应用于家用产品的阻燃化合物，直到 2004 年才被淘汰。PBDEs 是内分泌干扰物，据推测会影响与体重控制相关的信号。产前暴露于 PBDEs 可能会改变儿童肥胖，但很少有研究在人类群体中研究这些关联。
方法
数据来自于 1998 年至 2006 年期间从纽约市招募的多米尼加和非裔美国母婴队列的一项出生队列研究。在脐带血浆 (ng/μL) 中测量了 PBDE 同系物 BDE-47、-99、-100 和 -153，并将其分为低（<80 百分位）和高（>80 百分位）暴露类别。在 5、7、9、11 岁时以及 8 至 14 岁的辅助访问时收集了身高和体重（n=289）。使用具有参与者随机截距的混合效应模型来评估个体 PBDE 同系物或 PBDE 总和与儿童 BMIz 分数（BMIz）之间的关联。为了评估 PBDEs 与随时间推移 BMIz 的变化之间的关联，拟合了包括 PBDE 类别与儿童年龄和（儿童年龄）之间相互作用的模型。定量计算用于研究 BMIz 与总 PBDE 混合物之间的关联。模型调整了基线母体协变量：种族、年龄、教育、生育次数、伴侣关系状况和接受公共援助，以及儿童协变量：儿童性别、脐带胆固醇和甘油三酯。
结果
5 岁时肥胖儿童的患病率为 24.2%，11 岁时增加到 30%。脐带中单个 PBDE 或总 PBDE 混合物的水平均与儿童期整体 BMIz 无关。在低 PBDE 或高 PBDE 儿童中，整个儿童期 BMIz 的变化没有差异。调整产后 PBDE 暴露后，结果相似。
结论
在多米尼加和非裔美国儿童的队列中，产前 PBDE 暴露与儿童生长轨迹无关。
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