鞣花酸对变形链球菌葡糖基转移酶的抑制作用。
Inhibitory Effects of Ellagic Acid on Glucosyltransferases from Mutans Streptococci.
作者信息
Sawamura S, Tonosaki Y, Hamada S
机构信息
a Nippon Flour Mills Co., Ltd., Central Laboratory , Nurumizu, Atsugi , Kanagawa 243 , Japan.
b Department of Oral Microbiology , Osaka University Faculty of Dentistry , Yamadaoka, Suita , Osaka 565 , Japan.
出版信息
Biosci Biotechnol Biochem. 1992 Jan;56(5):766-8. doi: 10.1271/bbb.56.766.
Ellagic acid and its derivatives were found to abrogate the enzymatic activity of the glucosyltransferases (GTases) of mutans streptococci. These compounds preferentially inhibited the water-soluble glucan synthesis by GTase of Streptococcus mutans MT8148 and inhibited the water-insoluble glucan synthesis by GTase of Streptococcus sobrinus 6715. This inhibition resulted in a reduction of cellular adherence of mutans streptococci to a glass surface.
发现鞣花酸及其衍生物可消除变形链球菌葡糖基转移酶（GTases）的酶活性。这些化合物优先抑制变形链球菌MT8148的GTase合成水溶性葡聚糖，并抑制远缘链球菌6715的GTase合成水不溶性葡聚糖。这种抑制作用导致变形链球菌对玻璃表面的细胞黏附减少。
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