Nakano Fusako, Miyoshi Shozo, Murakami Toshiyuki
Maruzen Pharmaceuticals Co.Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, Hiroshima, 729-3102, Japan.
J Nat Med. 2017 Jul;71(3):545-552. doi: 10.1007/s11418-017-1090-9. Epub 2017 Apr 28.
Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A-D (1-4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by extensive spectroscopic analyses and the absolute configurations of 1-4 were determined by chemical and phytochemical evidence. These GOD-type ellagitannins inhibited the formation of dental plaque, which is beneficial for oral hygiene.
从甜茶（Rubus suavissimus）叶中分离出四种新的没食子酰氧基二苯基（GOD）型鞣花单宁，即悬钩子素A-D（1-4）。通过广泛的光谱分析阐明了它们的结构，并通过化学和植物化学证据确定了1-4的绝对构型。这些GOD型鞣花单宁可抑制牙菌斑的形成，这对口腔卫生有益。
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