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食用草莓通过抑制氧化应激减轻阿霉素诱导的毒性。

Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress.

作者信息

Giampieri Francesca, Alvarez-Suarez Jose M, Gasparrini Massimiliano, Forbes-Hernandez Tamara Y, Afrin Sadia, Bompadre Stefano, Rubini Corrado, Zizzi Antonio, Astolfi Paola, Santos-Buelga Celestino, González-Paramás Ana M, Quiles Josè L, Mezzetti Bruno, Battino Maurizio

机构信息

Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy.

Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy; Escuela de Medicina Veterinaria y Zootecnia, Facultad de Ciencias de la Salud. Universidad de Las Américas, Campus Queri, Quito, Ecuador.

出版信息

Food Chem Toxicol. 2016 Aug;94:128-37. doi: 10.1016/j.fct.2016.06.003. Epub 2016 Jun 7.

Abstract

Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds.

摘要

阿霉素(Dox)是最常用的化疗药物之一,已知其会产生氧化应激并阻断DNA合成,从而导致严重的剂量限制性毒性。预防阿霉素毒性作用的一种策略可能是使用饮食中的抗氧化剂,水果和蔬菜是其丰富来源。在这种情况下,由于草莓生物活性化合物的抗氧化能力,食用草莓与维持良好健康状态及预防多种疾病有关。本研究的目的是评估食用草莓对阿霉素诱导的大鼠氧化应激的保护作用。给动物喂食富含草莓的饮食(占总热量的15%),持续两个月,并在实验期结束时注射阿霉素(10毫克/千克;腹腔注射)。食用草莓显著抑制了血浆和肝组织中活性氧的产生以及氧化损伤生物标志物的积累,并减轻了用阿霉素处理的大鼠肝脏的组织病理学变化。食用草莓后,抗氧化酶活性的降低得到了显著缓解。此外,富含草莓的饮食改善了肝脏线粒体的抗氧化水平和功能。总之,由于草莓富含生物活性化合物,摄入草莓可在血浆、肝脏和线粒体水平预防阿霉素诱导的毒性。

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