• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

GenVisR:R语言中的基因组可视化

GenVisR: Genomic Visualizations in R.

作者信息

Skidmore Zachary L, Wagner Alex H, Lesurf Robert, Campbell Katie M, Kunisaki Jason, Griffith Obi L, Griffith Malachi

机构信息

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Department of Medicine Siteman Cancer Center Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Bioinformatics. 2016 Oct 1;32(19):3012-4. doi: 10.1093/bioinformatics/btw325. Epub 2016 Jun 10.

DOI:10.1093/bioinformatics/btw325
PMID:27288499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5039916/
Abstract

UNLABELLED

Visualizing and summarizing data from genomic studies continues to be a challenge. Here, we introduce the GenVisR package to addresses this challenge by providing highly customizable, publication-quality graphics focused on cohort level genome analyses. GenVisR provides a rapid and easy-to-use suite of genomic visualization tools, while maintaining a high degree of flexibility by leveraging the abilities of ggplot2 and Bioconductor.

AVAILABILITY AND IMPLEMENTATION

GenVisR is an R package available via Bioconductor (https://bioconductor.org/packages/GenVisR) under GPLv3. Support is available via GitHub (https://github.com/griffithlab/GenVisR/issues) and the Bioconductor support website.

CONTACTS

obigriffith@wustl.edu or mgriffit@wustl.edu

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.

摘要

未标注

对基因组研究的数据进行可视化和汇总仍然是一项挑战。在此,我们引入GenVisR软件包,通过提供高度可定制的、符合发表标准的图形来应对这一挑战,这些图形专注于队列水平的基因组分析。GenVisR提供了一套快速且易于使用的基因组可视化工具,同时通过利用ggplot2和Bioconductor的功能保持了高度的灵活性。

可用性和实现方式

GenVisR是一个通过Bioconductor(https://bioconductor.org/packages/GenVisR)以GPLv3协议提供的R软件包。可通过GitHub(https://github.com/griffithlab/GenVisR/issues)和Bioconductor支持网站获得支持。

联系方式

obigriffith@wustl.edu或mgriffit@wustl.edu

补充信息

补充数据可在《生物信息学》在线版获取。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c578/5039916/3d377da64075/btw325f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c578/5039916/3d377da64075/btw325f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c578/5039916/3d377da64075/btw325f1p.jpg

相似文献

1
GenVisR: Genomic Visualizations in R.GenVisR:R语言中的基因组可视化
Bioinformatics. 2016 Oct 1;32(19):3012-4. doi: 10.1093/bioinformatics/btw325. Epub 2016 Jun 10.
2
Exploring the Genomic Landscape of Cancer Patient Cohorts with GenVisR.利用 GenVisR 探索癌症患者队列的基因组景观。
Curr Protoc. 2021 Sep;1(9):e252. doi: 10.1002/cpz1.252.
3
DNAshapeR: an R/Bioconductor package for DNA shape prediction and feature encoding.DNAshapeR:一个用于DNA形状预测和特征编码的R/Bioconductor软件包。
Bioinformatics. 2016 Apr 15;32(8):1211-3. doi: 10.1093/bioinformatics/btv735. Epub 2015 Dec 14.
4
HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data.希尔伯特曲线:一个用于基因组数据高分辨率可视化的 R/Bioconductor 包。
Bioinformatics. 2016 Aug 1;32(15):2372-4. doi: 10.1093/bioinformatics/btw161. Epub 2016 Mar 24.
5
PanViz: interactive visualization of the structure of functionally annotated pangenomes.PanViz:功能注释泛基因组结构的交互式可视化
Bioinformatics. 2017 Apr 1;33(7):1081-1082. doi: 10.1093/bioinformatics/btw761.
6
Plotgardener: cultivating precise multi-panel figures in R.Plotgardener:在 R 中种植精确的多面板图形。
Bioinformatics. 2022 Mar 28;38(7):2042-2045. doi: 10.1093/bioinformatics/btac057.
7
Sushi.R: flexible, quantitative and integrative genomic visualizations for publication-quality multi-panel figures.Sushi.R:用于高质量多面板图表出版的灵活、定量和综合基因组可视化工具。
Bioinformatics. 2014 Oct;30(19):2808-10. doi: 10.1093/bioinformatics/btu379. Epub 2014 Jun 5.
8
Triplex: an R/Bioconductor package for identification and visualization of potential intramolecular triplex patterns in DNA sequences.三重体:一个用于鉴定和可视化 DNA 序列中潜在的分子内三重体模式的 R/Bioconductor 包。
Bioinformatics. 2013 Aug 1;29(15):1900-1. doi: 10.1093/bioinformatics/btt299. Epub 2013 May 24.
9
rGREAT: an R/bioconductor package for functional enrichment on genomic regions.rGREAT:一个用于基因组区域功能富集的 R/bioconductor 包。
Bioinformatics. 2023 Jan 1;39(1). doi: 10.1093/bioinformatics/btac745.
10
karyoploteR: an R/Bioconductor package to plot customizable genomes displaying arbitrary data.karyoploteR:一个 R/Bioconductor 软件包,用于绘制可定制基因组,显示任意数据。
Bioinformatics. 2017 Oct 1;33(19):3088-3090. doi: 10.1093/bioinformatics/btx346.

引用本文的文献

1
MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer.MED12-STAT1-TAP2轴调节CD8 + T细胞的细胞毒性,并介导非小细胞肺癌的免疫治疗结果。
Funct Integr Genomics. 2025 Sep 1;25(1):182. doi: 10.1007/s10142-025-01690-2.
2
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma.全基因组体内CRISPR筛选确定GATOR1复合体为Myc驱动的淋巴瘤中的肿瘤抑制因子。
Nat Commun. 2025 Aug 21;16(1):7582. doi: 10.1038/s41467-025-62615-y.
3
Demonstrating the clinical utility of genomic profiling using cerebrospinal fluid to inform management of central nervous system tumors - a meta analysis of the literature.

本文引用的文献

1
A genomic analysis of Philadelphia chromosome-negative AML arising in patients with CML.对慢性粒细胞白血病患者中出现的费城染色体阴性急性髓系白血病的基因组分析。
Blood Cancer J. 2016 Apr 8;6(4):e413. doi: 10.1038/bcj.2016.18.
2
Exploring genomic alteration in pediatric cancer using ProteinPaint.使用ProteinPaint探索儿科癌症中的基因组改变。
Nat Genet. 2016 Jan;48(1):4-6. doi: 10.1038/ng.3466.
3
A Phase I Trial of BKM120 (Buparlisib) in Combination with Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer.
利用脑脊液进行基因组分析以指导中枢神经系统肿瘤管理的临床效用——文献的荟萃分析
J Liq Biopsy. 2025 Jul 25;9:100317. doi: 10.1016/j.jlb.2025.100317. eCollection 2025 Sep.
4
A lipid metabolism-related gene signature predicts prognosis after tamoxifen treatment in ER + breast cancer and reflects tumor microenvironment heterogeneity through single-cell analysis.一种脂质代谢相关基因特征可预测雌激素受体阳性乳腺癌患者接受他莫昔芬治疗后的预后,并通过单细胞分析反映肿瘤微环境的异质性。
BMC Med Genomics. 2025 Jul 31;18(1):123. doi: 10.1186/s12920-025-02194-5.
5
A prognostic model for stomach adenocarcinoma based on hypoxia- and immune-related genes.基于缺氧和免疫相关基因的胃腺癌预后模型
Arch Med Sci. 2023 Jun 17;21(3):1018-1035. doi: 10.5114/aoms/167481. eCollection 2025.
6
Construction of the graph genomes of Takifugu provides novel insights into the genomic mechanisms of population structure and migratory traits.构建红鳍东方鲀的图形基因组为种群结构和洄游特性的基因组机制提供了新见解。
BMC Biol. 2025 Jul 1;23(1):195. doi: 10.1186/s12915-025-02296-7.
7
Evaluation of the diagnostic concordance of FDA-approved PD-L1 assays in clear cell renal cell carcinoma.FDA批准的程序性死亡受体配体1(PD-L1)检测方法在肾透明细胞癌中的诊断一致性评估
Sci Rep. 2025 Jul 1;15(1):21253. doi: 10.1038/s41598-025-05697-4.
8
Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers.全基因组测序揭示了食管鳞状细胞癌相关生物标志物。
PLoS One. 2025 Jun 26;20(6):e0323915. doi: 10.1371/journal.pone.0323915. eCollection 2025.
9
Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in small cell lung cancer.基于铁死亡相关基因和肿瘤微环境浸润特征的小细胞肺癌分子亚型
Front Immunol. 2025 May 13;16:1574434. doi: 10.3389/fimmu.2025.1574434. eCollection 2025.
10
Common bean pan-genome reveals abundant variation patterns and relationships of stress response genes and pathways.普通菜豆泛基因组揭示了丰富的变异模式以及胁迫响应基因和途径之间的关系。
BMC Genomics. 2025 May 16;26(1):495. doi: 10.1186/s12864-025-11662-2.
BKM120(布帕利昔布)联合氟维司群用于绝经后雌激素受体阳性转移性乳腺癌女性患者的I期试验。
Clin Cancer Res. 2016 Apr 1;22(7):1583-91. doi: 10.1158/1078-0432.CCR-15-1745. Epub 2015 Nov 12.
4
DGIdb 2.0: mining clinically relevant drug-gene interactions.DGIdb 2.0:挖掘临床相关的药物-基因相互作用
Nucleic Acids Res. 2016 Jan 4;44(D1):D1036-44. doi: 10.1093/nar/gkv1165. Epub 2015 Nov 3.
5
Genome Modeling System: A Knowledge Management Platform for Genomics.基因组建模系统:一个用于基因组学的知识管理平台。
PLoS Comput Biol. 2015 Jul 9;11(7):e1004274. doi: 10.1371/journal.pcbi.1004274. eCollection 2015 Jul.
6
Prognostic significance of acquired copy-neutral loss of heterozygosity in acute myeloid leukemia.获得性拷贝数中性杂合性缺失在急性髓系白血病中的预后意义。
Cancer. 2015 Sep 1;121(17):2900-8. doi: 10.1002/cncr.29475. Epub 2015 May 29.
7
MAGI: visualization and collaborative annotation of genomic aberrations.MAGI:基因组畸变的可视化与协作注释
Nat Methods. 2015 Jun;12(6):483-4. doi: 10.1038/nmeth.3412.
8
Organizing knowledge to enable personalization of medicine in cancer.整合知识以实现癌症医学的个性化。
Genome Biol. 2014 Aug 27;15(8):438. doi: 10.1186/s13059-014-0438-7.
9
Modeling precision treatment of breast cancer.乳腺癌精准治疗建模
Genome Biol. 2013;14(10):R110. doi: 10.1186/gb-2013-14-10-r110.
10
Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callers.在癌症基因组测序数据中检测体细胞点突变:突变调用程序的比较。
Genome Med. 2013 Oct 11;5(10):91. doi: 10.1186/gm495. eCollection 2013.