Re-emergent tremor in Parkinson's disease: A clinical and electromyographic study.

BACKGROUND

Re-emergent tremor (ReT) in Parkinson's disease (PD) is the tremor that re-emerges after a variable period of latency while maintaining posture. The phenomenology and electrophysiological aspects of ReT have not been well characterized. The aims of this study were to characterize ReT clinically and electrophysiologically.

METHODS

Sixty three patients with tremor dominant PD were recruited and subjected to clinical and electrophysiological evaluations. Group 1 consisted of 26 patients with rest tremor (RT) and ReT and group 2 consisted of 37 patients with RT and postural tremor (PT). The presence of silent period of ReT was determined clinically and confirmed electrophysiologically.

RESULTS

The duration of illness was significantly shorter in patients with ReT as compared to patients without ReT (5.2±4.4years vs 7.4±4.5years, p=0.03). ReT was similar to RT in terms of both frequency (4.8±0.7Hz vs 4.7±0.6Hz, p=0.1) and pattern of contraction. The frequency of RT was not significantly different in the 2 groups (p=0.5). The mean duration of silent period was 8.1±8.7s.

CONCLUSIONS

A significantly shorter duration of illness was found in patients with ReT as compared to patients without ReT. ReT is similar to RT in terms of frequency and pattern of contraction. However, the presence of silent period may imply additional pathophysiological mechanisms.