Bambino Gesù Children's Hospital-IRCCS, Gene Expression-Microarrays Laboratory, Viale di San Paolo 15, 00146, Rome, Italy.
Bambino Gesù Children's Hospital-IRCCS, Gene Expression-Microarrays Laboratory, Viale di San Paolo 15, 00146, Rome, Italy.
Trends Microbiol. 2016 Oct;24(10):777-787. doi: 10.1016/j.tim.2016.05.005. Epub 2016 Jun 8.
Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us.
真核生物和原核生物都会产生含有 RNA 和其他分子的细胞外纳米囊泡，它们利用这些囊泡来进行交流。最近，通过粪便 microRNA 已经证明了人类和细菌之间存在种间交流。我们在这里提出了细菌如何通过膜囊泡内的 RNA 与人类相互作用，从而改变我们的表观基因组，从而填补空白并形成闭环。同时，有迹象表明可能存在更广泛的种间交流网络，它可能包含所有已知的生物领域。既然已经确定了与我们其他基因组的联系，我们也应该开始探索我们周围的“社交”网络。
