IRI Life Sciences, Humboldt University, 10115 Berlin, Germany.
IRI Life Sciences, Humboldt University, 10115 Berlin, Germany.
Biochim Biophys Acta Gene Regul Mech. 2020 Jul;1863(7):194519. doi: 10.1016/j.bbagrm.2020.194519. Epub 2020 Mar 3.
Extracellular vesicles (EVs) are released by cells from all kingdoms and represent one form of cell-cell interaction. This universal system of communication blurs cells type boundaries, offering an new avenue for pathogens to infect their hosts. EVs carry with them an arsenal of virulence factors that have been the focus of numerous studies. During the last years, the RNA content of EVs has also gained increasing attention, particularly in the context of infection. Secreted RNA in EVs (evRNA) from several bacterial pathogens have been characterised but the exact mechanisms promoting pathogenicity remain elusive. In this review, we evaluate the potential of such transcripts to directly interact with targets in infected cells and, by this, represent a novel angle of host cell manipulation during bacterial infection. This article is part of a Special Issue entitled: RNA and gene control in bacteria edited by Dr. M. Guillier and F. Repoila.
细胞外囊泡 (EVs) 是所有生物界细胞释放的一种细胞间相互作用的形式。这种普遍的通讯系统模糊了细胞类型的界限，为病原体感染宿主提供了新的途径。EVs 携带了大量的毒力因子，这些因子一直是众多研究的焦点。在过去的几年中，EVs 的 RNA 含量也越来越受到关注，特别是在感染的背景下。已经对几种细菌病原体的 EVs（evRNA）中的 RNA 内容进行了描述，但促进致病性的确切机制仍不清楚。在这篇综述中，我们评估了这些转录本与感染细胞中靶标直接相互作用的潜力，并通过这种方式，代表了细菌感染过程中宿主细胞操纵的一个新角度。本文是由 M. Guillier 和 F. Repoila 博士编辑的题为“细菌中的 RNA 和基因控制”的特刊的一部分。
