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儿童的脂质复苏:迅速做出的决定。

Lipid rescue in children: The prompt decision.

作者信息

Eizaga Rebollar Ramón, García Palacios María V, Morales Guerrero Javier, Torres Morera Luis M

机构信息

Department of Anesthesiology and Reanimation, Puerta del Mar University Hospital, Cádiz, Spain.

Department of Preventive Medicine and Public Health, Puerta del Mar University Hospital, Cádiz, Spain.

出版信息

J Clin Anesth. 2016 Aug;32:248-52. doi: 10.1016/j.jclinane.2016.03.018. Epub 2016 Apr 20.

DOI:10.1016/j.jclinane.2016.03.018
PMID:27290983
Abstract

We report the case of a 17-month-old child who underwent laparotomy under general anesthesia and caudal block. Electrocardiogram ST-T changes were observed after local anesthetic injection. The prompt use of Intralipid 30% was successful in normalizing ECG alterations. Our experience is consistent with previous literature, mainly carried out in adults. Thereby, we conduct a brief review of the subject in pediatrics. As a major conclusion, we strongly recommend the "fast-track" lipid rescue as soon as this severe complication is detected.

摘要

我们报告了一例17个月大的儿童,该患儿在全身麻醉和骶管阻滞下接受了剖腹手术。局部麻醉药注射后观察到心电图ST-T改变。迅速使用30%的脂肪乳成功使心电图改变恢复正常。我们的经验与先前主要在成人中进行的文献一致。因此,我们对儿科领域的这一主题进行简要综述。作为主要结论,我们强烈建议一旦发现这种严重并发症,应尽快进行“快速通道”脂肪乳解救。

相似文献

1
Lipid rescue in children: The prompt decision.儿童的脂质复苏:迅速做出的决定。
J Clin Anesth. 2016 Aug;32:248-52. doi: 10.1016/j.jclinane.2016.03.018. Epub 2016 Apr 20.
2
Evidence-based clinical update: Which local anesthetic drug for pediatric caudal block provides optimal efficacy with the fewest side effects?循证临床更新:哪种局部麻醉药用于小儿骶管阻滞能提供最佳疗效且副作用最少?
Can J Anaesth. 2010 Dec;57(12):1102-10. doi: 10.1007/s12630-010-9386-1. Epub 2010 Sep 16.
3
Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate.成功复苏一名新生儿布比卡因诱发的心脏毒性。
Paediatr Anaesth. 2010 Oct;20(10):955-7. doi: 10.1111/j.1460-9592.2010.03406.x.
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Use of Intralipid in an infant with impending cardiovascular collapse due to local anesthetic toxicity.在一名因局部麻醉药毒性而即将发生心血管衰竭的婴儿中使用脂肪乳剂。
J Anesth. 2009;23(3):439-41. doi: 10.1007/s00540-009-0754-3. Epub 2009 Aug 14.
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Early intralipid therapy may have prevented bupivacaine-associated cardiac arrest.早期脂肪乳剂治疗可能预防了布比卡因相关的心脏骤停。
Reg Anesth Pain Med. 2008 Mar-Apr;33(2):178-80. doi: 10.1016/j.rapm.2007.09.006.
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Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid.用脂质乳剂治疗左旋布比卡因引起的癫痫发作和心血管虚脱。
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Use of intralipid for local anesthetic toxicity in neonates.在新生儿中使用脂肪乳剂治疗局部麻醉药中毒。
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Lipid infusion rescue for bupivacaine-induced cardiac arrest after axillary block.脂质输注挽救腋路阻滞后布比卡因所致心脏骤停。
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Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest.布比卡因诱导的心脏骤停经脂质复苏后心脏毒性的复发。
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引用本文的文献

1
Lipid emulsion treatment for local anesthetic systemic toxicity in pediatric patients: A systematic review.脂质乳剂治疗小儿局部麻醉药全身毒性:系统评价。
Medicine (Baltimore). 2024 Mar 15;103(11):e37534. doi: 10.1097/MD.0000000000037534.
2
Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report.婴儿静脉内误注入左旋布比卡因后发生局部麻醉药全身毒性:病例报告。
Medicina (Kaunas). 2023 May 19;59(5):981. doi: 10.3390/medicina59050981.
3
Mechanisms and Efficacy of Intravenous Lipid Emulsion Treatment for Systemic Toxicity From Local Anesthetics.
局部麻醉药全身毒性的静脉注射脂质乳剂治疗机制及疗效
Front Med (Lausanne). 2021 Nov 8;8:756866. doi: 10.3389/fmed.2021.756866. eCollection 2021.
4
Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.左旋布比卡因的临床药代动力学与药效学
Clin Pharmacokinet. 2020 Jun;59(6):715-745. doi: 10.1007/s40262-020-00868-0.
5
Lipid emulsion therapy of local anesthetic systemic toxicity due to dental anesthesia.脂质乳剂治疗牙科麻醉引起的局部麻醉药全身毒性反应
J Dent Anesth Pain Med. 2019 Aug;19(4):181-189. doi: 10.17245/jdapm.2019.19.4.181. Epub 2019 Aug 30.