Jain K S, Arya N, Inamdar N N, Auti P B, Unawane S A, Puranik H H, Sanap M S, Inamke A D, Mahale V J, Prajapati C S, Shishoo C J
R.M. Dhariwal Institute of Pharmaceutical Education & Research, Chinchwad, Pune, India.
Curr Top Med Chem. 2016;16(28):3133-3174. doi: 10.2174/1568026616666160609100410.
This review discusses the biological and medicinal significance of one of the most important and interesting heterocyclic ring systems, the pyrimidine and its condensed derivatives. Herein, various physiologically important molecules, as well as, therapeutically used drugs having a pyrimidine or condensed pyrimidine system in their chemical structures, have been covered. The chemistry and synthesis of pyrimidines have also been briefly discussed.
本综述讨论了最重要且最有趣的杂环体系之一——嘧啶及其稠合衍生物的生物学和医学意义。本文涵盖了各种具有生理重要性的分子,以及化学结构中含有嘧啶或稠合嘧啶体系的治疗用药物。还简要讨论了嘧啶的化学和合成。