Farrow D C, Weiss N S, Lyon J L, Daling J R
Department of Epidemiology, University of Washington, Seattle.
Am J Epidemiol. 1989 Jun;129(6):1300-4. doi: 10.1093/oxfordjournals.aje.a115249.
Data from a population-based case-control study conducted in Washington State and Utah were used to assess whether obesity is associated with an altered risk of epithelial ovarian cancer. Quetelet index, defined as weight (kg) at age 30 years divided by height (m) squared, was calculated for each woman, and the values for all subjects were divided into five categories of approximately equal size. Compared with women in the lowest category, women in the highest category had an odds ratio of 1.7 (95 per cent CI 1.1-2.7). Risks for women in the three intermediate Quetelet index categories also exceeded the risk for women in the lowest group, but to a much smaller degree. Among women with serous tumors, those in the highest Quetelet index category were at a greater than twofold excess risk (OR = 2.2, 95 per cent CI 1.1-4.2), but the risk was not increased in the intermediate categories. For endometrioid tumors, risk increased consistently with increasing Quetelet index, and the odds ratio in the highest category was 4.7 (95 per cent CI 1.0-22.7). For both serous and endometrioid tumors, the excess risk was largely confined to premenopausal women. The results of this analysis suggest that for at least some types of ovarian tumor, obesity may warrant further attention as a possible etiologic factor.
一项在华盛顿州和犹他州开展的基于人群的病例对照研究数据，被用于评估肥胖是否与上皮性卵巢癌风险的改变有关。计算了每位女性的奎特利指数（定义为30岁时的体重（千克）除以身高（米）的平方），并将所有受试者的数值分为大致相等的五个类别。与最低类别组的女性相比，最高类别组的女性优势比为1.7（95%置信区间1.1 - 2.7）。奎特利指数处于中间三个类别的女性风险也超过了最低组女性的风险，但程度要小得多。在患有浆液性肿瘤的女性中，奎特利指数最高类别组的女性风险高出两倍多（优势比 = 2.2，95%置信区间1.1 - 4.2），但中间类别组的风险并未增加。对于子宫内膜样肿瘤，风险随着奎特利指数的增加而持续上升，最高类别组的优势比为4.7（95%置信区间1.0 - 22.7）。对于浆液性和子宫内膜样肿瘤，额外风险主要局限于绝经前女性。该分析结果表明，对于至少某些类型的卵巢肿瘤，肥胖作为一种可能的病因因素可能值得进一步关注。
