Liu Qian, Huang Yinghong, Zhang Ronghua, Cai Tiange, Cai Yu
College of Pharmacy, Jinan University, Guangzhou 510632, China.
College of Life Sciences, Liaoning University, Shenyang 110036, China.
Evid Based Complement Alternat Med. 2016;2016:7803846. doi: 10.1155/2016/7803846. Epub 2016 May 11.
Along with the development of marine biological pharmaceutical research, high-effective and low-toxic drugs and functional foods isolated from marine organisms have become a new field of pharmacy and bromatology. The pharmacological actions, such as anti-inflammation, antioxidation, antitumor, immunological enhancement, and hepatorenal protection of C-phycocyanin (C-PC) from Spirulina platensis, have been reported, and C-PC has important value of development and utilization either as drug or as functional food. There are many researches about the various pharmacological actions and mechanisms of C-PC, but related reports are only to some extent integrated deeply and accurately enough, which put some limitations to the further application of C-PC in medicine. Particularly, with the improvement of living standards and attention to health issues, C-PC being a functional food is preferred by more and more people. C-PC is easy to get, safe, and nontoxic; thus, it has a great potential of research and development as a drug or functional food. Here, the separation and purification, physicochemical properties, physiological and pharmacological activities, safety, and some applications are reviewed to provide relevant basis for the development of natural medicine and applied products.
随着海洋生物药物研究的发展，从海洋生物中分离出的高效低毒药物和功能性食品已成为药学和营养学的一个新领域。钝顶螺旋藻C-藻蓝蛋白（C-PC）的抗炎、抗氧化、抗肿瘤、免疫增强及肝肾保护等药理作用已有报道，C-PC作为药物或功能性食品均具有重要的开发利用价值。关于C-PC的各种药理作用及机制已有诸多研究，但相关报道在深度和准确性上仅在一定程度上有所整合，这给C-PC在医学上的进一步应用带来了一些限制。特别是随着生活水平的提高和对健康问题的关注，C-PC作为功能性食品越来越受到人们的青睐。C-PC易于获取、安全无毒，因此作为药物或功能性食品具有很大的研发潜力。在此，对其分离纯化、理化性质、生理药理活性、安全性及一些应用进行综述，为天然药物及应用产品的开发提供相关依据。
