Turner B J, Siatkowski R M, Augsburger J J, Shields J A, Lustbader E, Mastrangelo M J
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Am J Ophthalmol. 1989 Jun 15;107(6):601-8. doi: 10.1016/0002-9394(89)90256-0.
To determine associations with other cancers, 400 consecutive uveal melanoma patients examined at Wills Eye Hospital between 1984 and 1985 were surveyed regarding personal and family history of cancer. Responses were received from 333 (83%). Sixty patients reported 43 nonbasal cell second primary cancers, which were confirmed pathologically or by physician records. The overall prevalence of nonbasal cell cancers diagnosed in uveal melanoma patients by December 1985 was over two times greater than the expected prevalence, based on the Connecticut Tumor Registry data for an age- and sex-matched population. Gynecologic cancers tended to be more common in uveal melanoma female patients than in the comparison population. Although the observed prevalence of cutaneous melanoma was not significantly greater than expected, three cases with both primary cutaneous and uveal melanoma were reported. Family histories of cutaneous melanoma were confirmed in 14 patients, and uveal melanoma in two patients. Data suggested that the overall cancer prevalence in uveal melanoma patients may be increased, that hormonal factors may play a role in the genesis of this malignancy, and that there may be a link between cutaneous and uveal melanoma.
为了确定与其他癌症的关联，对1984年至1985年间在威尔斯眼科医院接受检查的400例连续性葡萄膜黑色素瘤患者进行了关于个人和家族癌症病史的调查。共收到333例（83%）的回复。60例患者报告了43例非基底细胞第二原发性癌症，这些癌症经病理证实或有医生记录。根据康涅狄格肿瘤登记处针对年龄和性别匹配人群的数据，截至1985年12月，葡萄膜黑色素瘤患者中诊断出的非基底细胞癌总体患病率比预期患病率高出两倍多。妇科癌症在葡萄膜黑色素瘤女性患者中往往比在对照人群中更为常见。虽然观察到的皮肤黑色素瘤患病率并不显著高于预期，但报告了3例同时患有原发性皮肤和葡萄膜黑色素瘤的病例。14例患者的皮肤黑色素瘤家族史得到证实，2例患者的葡萄膜黑色素瘤家族史得到证实。数据表明，葡萄膜黑色素瘤患者的总体癌症患病率可能会增加，激素因素可能在这种恶性肿瘤的发生中起作用，并且皮肤和葡萄膜黑色素瘤之间可能存在联系。
