Schoenberg B S, Christine B W
South Med J. 1980 Nov;73(11):1493-7. doi: 10.1097/00007611-198011000-00023.
The experience of the population-based Connecticut Tumor Registry was analyzed for the occurrence in the same patient of breast cancer and malignant melanoma. A total of 18,010 women with breast cancer were followed up for the subsequent development of malignant melanoma of the skin or eye. Similarly, 835 women with cutaneous or ocular malignant melanoma were followed up for the subsequent development of breast carcinoma. Survival experience for these cohorts and appropriate Connecticut Tumor Registry incidence rates were used to calculate an expected number of individuals with both types of malignant neoplasms. Twenty-three women had both types of tumors diagnosed at least one month apart. Fewer than 14 such occurrences were expected (P < .05). The two tumors may be related through hormonal factors, particularly when considered with regard to the findings of other laboratory and epidemiologic studies.
对基于人群的康涅狄格肿瘤登记处的数据进行了分析，以研究乳腺癌和恶性黑色素瘤在同一患者身上的发生情况。总共对18010名乳腺癌女性患者进行了随访，观察其随后是否会发生皮肤或眼部恶性黑色素瘤。同样，对835名皮肤或眼部恶性黑色素瘤女性患者进行了随访，观察其随后是否会发生乳腺癌。利用这些队列的生存经验以及康涅狄格肿瘤登记处的适当发病率来计算同时患有这两种恶性肿瘤的预期人数。有23名女性被诊断患有这两种肿瘤，且诊断时间相隔至少一个月。预期此类病例少于14例（P < 0.05）。这两种肿瘤可能通过激素因素相关联，特别是结合其他实验室和流行病学研究的结果来看时。
