在男性运动及恢复过程中，甲状旁腺激素的分泌受离子钙和磷酸盐两者的控制。
Parathyroid Hormone Secretion Is Controlled by Both Ionized Calcium and Phosphate During Exercise and Recovery in Men.
作者信息
Townsend Rebecca, Elliott-Sale Kirsty J, Pinto Ana Jessica, Thomas Craig, Scott Jonathan P R, Currell Kevin, Fraser William D, Sale Craig
机构信息
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
出版信息
J Clin Endocrinol Metab. 2016 Aug;101(8):3231-9. doi: 10.1210/jc.2016-1848. Epub 2016 Jun 13.
CONTEXT
The mechanism by which PTH is controlled during and after exercise is poorly understood due to insufficient temporal frequency of measurements.
OBJECTIVE
The objective of the study was to examine the temporal pattern of PTH, PO4, albumin-adjusted calcium, and Ca(2+) during and after exercise.
DESIGN AND SETTING
This was a laboratory-based study with a crossover design, comparing 30 minutes of running at 55%, 65%, and 75% maximal oxygen consumption, followed by 2.5 hours of recovery. Blood was obtained at baseline, after 2.5, 5, 7.5, 10, 15, 20, 25, and 30 minutes of exercise, and after 2.5, 5, 7.5, 10, 15, 20, 25, 30, 60, 90, and 150 minutes of recovery.
PARTICIPANTS
Ten men (aged 23 ± 1 y, height 1.82 ± 0.07 m, body mass 77.0 ± 7.5 kg) participated.
MAIN OUTCOME MEASURES
PTH, PO4, albumin-adjusted calcium, and Ca(2+) were measured.
RESULTS
Independent of intensity, PTH concentrations decreased with the onset of exercise (-21% to -33%; P ≤ .001), increased thereafter, and were higher than baseline by the end of exercise at 75% maximal oxygen consumption (+52%; P ≤ .001). PTH peaked transiently after 5-7.5 minutes of recovery (+73% to +110%; P ≤ .001). PO4 followed a similar temporal pattern to PTH, and Ca(2+) followed a similar but inverse pattern to PTH. PTH was negatively correlated with Ca(2+) across all intensities (r = -0.739 to -0.790; P ≤ .001). When PTH was increasing, the strongest cross-correlation was with Ca(2+) at 0 lags (3.5 min) (r = -0.902 to -0.950); during recovery, the strongest cross-correlation was with PO4 at 0 lags (8 min) (r = 0.987-0.995).
CONCLUSIONS
PTH secretion during exercise and recovery is controlled by a combination of changes in Ca(2+) and PO4 in men.
背景
由于测量的时间频率不足，运动期间及运动后甲状旁腺激素（PTH）的控制机制尚不清楚。
目的
本研究的目的是研究运动期间及运动后PTH、磷酸根（PO4）、白蛋白校正钙和钙离子（Ca(2+)）的时间模式。
设计与环境
这是一项基于实验室的交叉设计研究，比较了在最大耗氧量的55%、65%和75%时进行30分钟跑步，随后进行2.5小时恢复的情况。在基线、运动2.5、5、7.5、10、15、20、25和30分钟后以及恢复2.5、5、7.5、10、15、20、25、30、60、90和150分钟后采集血液。
参与者
10名男性（年龄23±1岁，身高1.82±0.07米，体重77.0±7.5千克）参与。
主要观察指标
测量PTH、PO4、白蛋白校正钙和Ca(2+)。
结果
与运动强度无关，运动开始时PTH浓度下降（-21%至-33%；P≤0.001），此后升高，在最大耗氧量75%的运动结束时高于基线（+52%；P≤0.001）。PTH在恢复5-7.5分钟后短暂达到峰值（+73%至+110%；P≤0.001）。PO4的时间模式与PTH相似，而Ca(2+)的模式与PTH相似但相反。在所有强度下，PTH与Ca(2+)呈负相关（r=-0.739至-0.790；P≤0.001）。当PTH升高时，最强的交叉相关性是在0滞后（3.5分钟）时与Ca(2+)的相关性（r=-0.902至-0.950）；在恢复期间，最强的交叉相关性是在0滞后（8分钟）时与PO4的相关性（r=0.987-0.995）。
结论
男性运动和恢复期间PTH的分泌受Ca(2+)和PO4变化的共同控制。
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