Human Sciences (J.P.R.S., A.C.), QinetiQ Ltd, Farnborough GU14 0LX, United Kingdom; Biomedical, Life, and Health Sciences Research Centre (C.S.), School of Science and Technology, Nottingham Trent University, NG1 4BU Nottingham, United Kingdom; Department of Occupational Medicine (J.P.G.), Headquarters Army Recruiting and Training Division, Upavon SN9 6BE, Wiltshire, United Kingdom; Department of Musculoskeletal Biology (J.D.), University of Liverpool, Liverpool L69 7ZX, United Kingdom; and Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ United Kingdom.
J Clin Endocrinol Metab. 2014 May;99(5):1774-82. doi: 10.1210/jc.2013-3027. Epub 2014 Jan 29.
Lower PTH concentrations reported in the hours after acute, endurance exercise compared with preexercise levels might be influenced by factors such as circadian fluctuations.
The objective of the study was to compare postexercise PTH concentrations with a nonexercising control group.
A laboratory-based study with a crossover design, comparing a 60-minute (at 10:30 am) bout of treadmill running at 65% of the maximal rate of oxygen uptake (exercise) with semirecumbent rest (CON). Blood samples were obtained immediately before (baseline 10:15 am) and after (11:30 am) exercise and during recovery (12:30 am, 1:30 pm, and 2:15 pm).
Ten physically active men (mean ± 1 SD, age 26 ± 5 y; body mass 78.3 ± 5.8 kg; maximal rate of oxygen uptake 57.3 ± 6.9 mL/kg(-1) · min(-1)) participated in the study.
PTH, albumin-adjusted calcium, and phosphate concentrations were measured.
PTH concentrations increased (+85%, P < .01) during exercise and were higher than in CON immediately at the end of exercise (4.5 ± 1.9 vs 2.6 ± 0.9 pmol/L(-1), P < .05). In the postexercise period (12:30-2:15 pm), PTH was not different compared with baseline but was lower compared with CON at 1:30 pm (-22%; P < .01) and tended to be lower at both 12:30 pm (-12%; P = .063) and 2:15 pm (-13%; P = .057). Exercise did not significantly affect the albumin-adjusted calcium concentrations, whereas phosphate was higher than CON immediately after exercise (1.47 ± 0.17 vs 1.03 ± 0.17 pmol/L(-1), P < .001) and was lower at 1:30 pm (-16%: P < .05).
Lower PTH concentrations after acute endurance running compared with a rested control condition suggest a true effect of exercise.
与运动前水平相比，急性耐力运动后几小时内报告的较低甲状旁腺激素（PTH）浓度可能受昼夜波动等因素的影响。
本研究的目的是比较运动后与非运动对照组的 PTH 浓度。
一项基于实验室的研究，采用交叉设计，比较 60 分钟（上午 10：30）以最大摄氧量的 65%进行的跑步机跑步（运动）与半卧位休息（CON）。在运动前（上午 10：15，基线）和运动后（上午 11：30）以及恢复期间（上午 12：30、下午 1：30 和下午 2：15）采集血液样本。
10 名体能活跃的男性（平均±1 SD，年龄 26±5 岁；体重 78.3±5.8kg；最大摄氧量 57.3±6.9mL/kg·min）参与了这项研究。
甲状旁腺激素、白蛋白校正钙和磷酸盐浓度。
PTH 浓度在运动过程中增加（+85%，P<.01），运动结束时立即高于 CON（4.5±1.9 比 2.6±0.9 pmol/L，P<.05）。在运动后的时期（下午 12：30-2：15），与基线相比，PTH 没有差异，但与 CON 相比，下午 1：30 时更低（-22%，P<.01），下午 12：30 时也呈下降趋势（-12%，P=0.063），下午 2：15 时（-13%，P=0.057）。运动没有显著影响白蛋白校正钙浓度，而磷酸盐在运动后立即高于 CON（1.47±0.17 比 1.03±0.17 pmol/L，P<.001），下午 1：30 时更低（-16%，P<.05）。
与休息对照条件相比，急性耐力运动后较低的 PTH 浓度表明运动确实有影响。
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