Whited Matthew C, Olendzki Effie, Ma Yunsheng, Waring Molly E, Schneider Kristin L, Appelhans Bradley M, Busch Andrew M, Chesebro James, Pagoto Sherry L
Department of Psychology.
Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School.
Health Psychol. 2016 Dec;35(12):1316-1319. doi: 10.1037/hea0000379. Epub 2016 Jun 13.
The purpose of this study was to examine whether adults with obesity and metabolic syndrome who screen as high risk for obstructive sleep apnea (OSA) lose less weight as part of a weight loss intervention than those who screen as low risk.
We conducted a secondary analysis of a randomized trial comparing 2 weight loss interventions consisting of dietary counseling for adults with obesity and metabolic syndrome. Participants were screened for sleep apnea using a validated screening questionnaire. Percent weight loss was calculated from weight measured at baseline and intervention end (12 months). Weight loss of 5% or greater was considered clinically significant. Multivariate linear and logistic regression models estimated the association between OSA screening status (high vs. low risk) and percent weight loss and clinically significant weight loss, adjusting for relevant covariates including body mass index and sleep duration.
Nearly half of participants (45.8%) screened as high risk for OSA. Participants who screened as high risk for OSA lost less weight (1.2% ± 4.2% vs. 4.2% ± 5.3%) and were less likely to lose 5% or greater (24.4% vs. 75.6%) than participants without OSA.
Among adults with obesity and metabolic syndrome, those at high risk for OSA lost less weight in response to a dietary counseling intervention than adults with low risk of OSA. Routine OSA screening should be considered as part of weight loss treatment programs. Additional research is needed to determine how to tailor weight loss treatment for those with high risk for OSA. (PsycINFO Database Record
本研究旨在探讨肥胖和代谢综合征成人中，筛查为阻塞性睡眠呼吸暂停（OSA）高风险的人群在减肥干预中体重减轻是否比筛查为低风险的人群少。
我们对一项随机试验进行了二次分析，该试验比较了两种针对肥胖和代谢综合征成人的减肥干预措施，即饮食咨询。使用经过验证的筛查问卷对参与者进行睡眠呼吸暂停筛查。根据基线和干预结束时（12个月）测量的体重计算体重减轻百分比。体重减轻5%或更多被认为具有临床意义。多变量线性和逻辑回归模型估计了OSA筛查状态（高风险与低风险）与体重减轻百分比和具有临床意义的体重减轻之间的关联，并对包括体重指数和睡眠时间在内的相关协变量进行了调整。
近一半的参与者（45.8%）筛查为OSA高风险。与无OSA的参与者相比，筛查为OSA高风险的参与者体重减轻较少（1.2%±4.2%对4.2%±5.3%），且体重减轻5%或更多可能性较小（24.4%对75.6%）。
在肥胖和代谢综合征成人中，OSA高风险者对饮食咨询干预的体重减轻比OSA低风险者少。应考虑将常规OSA筛查作为减肥治疗计划的一部分。需要进一步研究以确定如何为OSA高风险者量身定制减肥治疗方案。（PsycINFO数据库记录）
