Seckin Berna, Pekcan Meryem Kuru, Inal Hasan Ali, Gulerman Cavidan
Department of Reproductive Endocrinology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
Department of Gynecology and Obstetrics, Konya Training and Research Hospital, Konya, Turkey.
Aging Clin Exp Res. 2017 Jun;29(3):537-541. doi: 10.1007/s40520-016-0599-1. Epub 2016 Jun 13.
Estrogen is known to affect both mammographic breast density and bone mineral density (BMD), but there are inconsistent results about the association of these density measurements in postmenopausal women. Furthermore, there are scarce data on the relationship between breast density and BMD in never users of postmenopausal hormone therapy.
In this study, we examined the relationship between mammographic breast density and BMD in postmenopausal women who were never hormone replacement therapy users.
A total of 293 postmenopausal women were enrolled in this cross-sectional study. Mammograms and BMD measurements for screening purposes were obtained. Assessment of mammographic breast density was performed by using breast imaging reporting and data system classification. The BMD was measured using dual-energy X-ray absorptiometry of the lumbar spine and femoral neck.
Grade 1 breast density was observed in 64 women (21.8 %), grade 2 in 113 women (38.6 %) and grades 3 and 4 in 116 (39.6 %) women. Breast density decreased with increasing age and body mass index (BMI). Meanwhile, no significant differences were detected in BMD measures of the hip (p = 0.14) and lumbar spine (p = 0.29) among the breast density categories. After adjusting for age and BMI, the differences in the mean BMD at the hip and lumbar spine across the breast density categories remained insignificant (p = 0.26 and 0.11, respectively).
There is no evidence of a relationship between mammographic breast density and BMD in postmenopausal women who had never used hormone replacement therapy.
已知雌激素会影响乳腺钼靶密度和骨矿物质密度（BMD），但绝经后女性中这些密度测量值之间的关联结果并不一致。此外，关于从未使用过绝经后激素治疗的女性乳腺密度与骨密度之间的关系，数据稀缺。
在本研究中，我们调查了从未使用过激素替代疗法的绝经后女性乳腺钼靶密度与骨密度之间的关系。
本横断面研究共纳入293名绝经后女性。获取用于筛查目的的乳房X光片和骨密度测量值。采用乳腺影像报告和数据系统分类法评估乳腺钼靶密度。使用双能X线吸收法测量腰椎和股骨颈的骨密度。
64名女性（21.8%）观察到1级乳腺密度，113名女性（38.6%）为2级，116名女性（39.6%）为3级和4级。乳腺密度随年龄和体重指数（BMI）增加而降低。同时，各乳腺密度类别之间的髋部（p = 0.14）和腰椎（p = 0.29）骨密度测量值未检测到显著差异。在调整年龄和BMI后，各乳腺密度类别之间髋部和腰椎的平均骨密度差异仍不显著（分别为p = 0.26和0.11）。
在从未使用过激素替代疗法的绝经后女性中，没有证据表明乳腺钼靶密度与骨密度之间存在关联。
