基于本地疫情信息诊断输入性乌干达伤寒热：一例病例报告。

Diagnosis of imported Ugandan typhoid fever based on local outbreak information: A case report.

作者信息

Ota Shinichiro, Maki Yohei, Mori Kazuma, Hamamoto Takaaki, Kurokawa Atsushi, Ishihara Masashi, Yamamoto Takayuki, Imai Kazuo, Misawa Kazuhisa, Yuki Atsushi, Fujikura Yuji, Maeda Takuya, Kawana Akihiko

机构信息

Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

Department of Laboratory Medicine, National Defense Medical College Hospital, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

出版信息

J Infect Chemother. 2016 Nov;22(11):770-773. doi: 10.1016/j.jiac.2016.05.004. Epub 2016 Jun 11.

DOI:10.1016/j.jiac.2016.05.004

PMID:27297635

Abstract

Re-emerging multidrug-resistant typhoid fever is becoming a worldwide threat, especially in East Africa. At the beginning of 2015, an outbreak of typhoid fever started in the capital city of Uganda, and 1940 suspected cases were reported by 5 March 2015. In this report, we describe a case of typhoid fever caused by a MDR strain with HIV infection and hemoglobin S-syndrome thalassemia in an Ugandan from Kampala City. It is essential to consider MDR strains of Salmonella enterica serovar Typhi infections, including fluoroquinolone-resistant strains, in patients from Africa and Southeast Asia.

摘要

再度出现的多重耐药伤寒热正成为一个全球性威胁，尤其是在东非。2015年初，乌干达首都爆发了伤寒热疫情，截至2015年3月5日报告了1940例疑似病例。在本报告中，我们描述了一例由多重耐药菌株引起的伤寒热病例，患者为一名来自坎帕拉市的乌干达人，同时感染了艾滋病毒并患有血红蛋白S-地中海贫血综合征。对于来自非洲和东南亚的患者，必须考虑感染肠沙门氏菌血清型伤寒的多重耐药菌株，包括耐氟喹诺酮菌株。