Fifth Affiliated Hospital, Southern Medical University, Clinical Laboratory, Guangzhou, China.
Obstetrics Department, Second People's Hospital of Yibin, Yibin, China.
Front Cell Infect Microbiol. 2022 Feb 2;12:805384. doi: 10.3389/fcimb.2022.805384. eCollection 2022.
infection is a major public health concern worldwide, has contributed to an increased economic burden on the health systems. Non-typhoidal (NTS) is a common cause of bacterial enteritis in humans, causing 93.8 million cases of gastroenteritis globally each year, with 155,000 deaths. Guangzhou city is situated in the south of China and has a sub-tropical climate, the heat and heavy rainfall helps the spread of NTS. However, no information of NTS infection is available in humans in Conghua District, the largest administrative district of Guangzhou. To understand the prevalence, serotype distribution, risk factors and drug resistance of NTS infection in humans in the survey area, an epidemiological investigation was conducted in hospitalized patients in Conghua District in Guangzhou, China. A total of 255 fecal specimens were collected from hospitalized patients (one each), with a questionnaire for each participant, and NTS infection was identified by culture, as well as serotypes confirmed by slide agglutination tests. An average prevalence of 20.39% (52/255) was observed and three serogroups were identified-serogroup B (n = 46), serogroup C1 (n = 4) and serogroup D1 (n = 2). Among them, Typhimurium (n = 39) was the most common serotype. Children aged <3 years were observed to have a statistically higher prevalence of NTS infection than adults (25.15% versus 4.65%, P = 0.006); children with artificial feeding had a statistically higher prevalence than those with breastfeeding (30.77% versus 8.33%, P = 0.044). Antimicrobial resistance testing revealed that the majority of strains were resistant to ampicillin (92.16%), as well as 47.06% of all strains were multi-drug resistant. Therefore, it is necessary to continuous monitoring and rational use of antibiotics, which will be helpful to reduce the prevalence of resistant strains. These data will aid in making efficient control strategies to intervene with and prevent occurrence of salmonellosis.
感染是全球主要的公共卫生关注点之一，导致卫生系统的经济负担增加。非伤寒型（NTS）是人类细菌性肠炎的常见原因，每年导致全球 9380 万例胃肠炎，有 15.5 万人死亡。广州市位于中国南部，气候属亚热带，高温和大雨有助于 NTS 的传播。然而，在广州最大的行政区从化区，尚无人类 NTS 感染的信息。为了解从化区人类 NTS 感染的流行率、血清型分布、危险因素和耐药性，在中国广州从化区对住院患者进行了一项流行病学调查。从住院患者（每人 1 份）中采集了 255 份粪便标本，对每位参与者进行了问卷调查，并通过培养鉴定 NTS 感染，通过玻片凝集试验确定血清型。观察到平均流行率为 20.39%（52/255），鉴定出 3 个血清群-血清群 B（n = 46）、血清群 C1（n = 4）和血清群 D1（n = 2）。其中，鼠伤寒血清型（n = 39）是最常见的血清型。与成年人相比，年龄<3 岁的儿童 NTS 感染的流行率更高（25.15%对 4.65%，P = 0.006）；人工喂养的儿童比母乳喂养的儿童感染率更高（30.77%对 8.33%，P = 0.044）。药敏试验显示，大多数菌株对氨苄西林耐药（92.16%），47.06%的菌株为多重耐药。因此，需要对耐药菌株进行持续监测和合理使用抗生素，这将有助于降低耐药菌株的流行率。这些数据将有助于制定有效的控制策略，干预和预防沙门氏菌病的发生。
