Fuhrmann U, Rieger M, Franz Ch
Dtsch Med Wochenschr. 1978 Mar 3;103(9):387-90. doi: 10.1055/s-0028-1104444.
During cytostatic combination treatment with five different anti-tumor agents two female patients suffered from cardiac failure which proved fatal. This was mainly due to doxorubicine (adriamycin) and daunorubicine. In an 8-year-old patient the cumulative dose was reached after 14 months of treatment (total dose of adriamycin 420 mg/m2, of daunorubicine 280 mg/m2) and in a 7-year-old patient after 16 months (total dose of adriamycin 480 mg/m2, of daunorubicine 280 mg/m2). Cardiac failure which occurred 12 months after the onset of treatment in a 12-year-old girl (total dose of adriamycin 310 mg/m2 and of daunorubicine 280 mg/m2) could be brought under control. The cumulative dose of adriamycin should be limited to 500 mg/m2 in children without risk factors.
在使用五种不同抗肿瘤药物进行细胞抑制联合治疗期间，两名女性患者出现心力衰竭并最终死亡。这主要归因于多柔比星（阿霉素）和柔红霉素。一名8岁患者在治疗14个月后达到累积剂量（阿霉素总剂量420mg/m²，柔红霉素总剂量280mg/m²），一名7岁患者在16个月后达到累积剂量（阿霉素总剂量480mg/m²，柔红霉素总剂量280mg/m²）。一名12岁女孩在治疗开始12个月后出现心力衰竭（阿霉素总剂量310mg/m²，柔红霉素总剂量280mg/m²），但病情得到了控制。对于没有危险因素的儿童，阿霉素的累积剂量应限制在500mg/m²以内。
