Stopfkuchen H, Gutjahr P
Klin Padiatr. 1976 Sep;188(5):459-63.
Nephrectomy with irradiation was performed in a 3;2 year old boy with Wilms tumor stage IV (livermetastases (liver metastases). Six months later a hemihepatectomy was performed on account of the liver metatases which persisted under a combined Actinomycin Vincristin therapy. A monotherapy with Adriamycin was instituted. The patient developed acute congestive heart failure. The patient developed acute congestive heart failure and showed typical EKG changes after a total dose of 700 mg/M2 of Adriamycin. In comparison to adults children reportedly tolerate somewhat higher total doses of Adriamycin. Therefore it is discussed, if in this case a limitation of liver function by hemihepatectomy and by irradiation has favored the appearance of the Adriamycin-induced cardiomyopathy.
对一名3岁2个月大患有IV期威尔姆斯瘤（肝转移）的男孩进行了肾切除术并放疗。6个月后，由于在放线菌素联合长春新碱治疗下肝转移仍持续存在，遂进行了半肝切除术。随后采用阿霉素单药治疗。患者出现了急性充血性心力衰竭。在阿霉素总剂量达到700mg/M²后，患者出现急性充血性心力衰竭并伴有典型的心电图变化。据报道，与成人相比，儿童能耐受稍高剂量的阿霉素。因此，有人讨论在这种情况下，半肝切除术和放疗导致的肝功能受限是否促使了阿霉素诱发的心肌病的出现。
