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与抗磷脂抗体相关的一过性黑矇

Amaurosis fugax associated with antiphospholipid antibodies.

作者信息

Digre K B, Durcan F J, Branch D W, Jacobson D M, Varner M W, Baringer J R

机构信息

Department of Neurology, University of Utah Medical Center, Salt Lake City 84132.

出版信息

Ann Neurol. 1989 Mar;25(3):228-32. doi: 10.1002/ana.410250304.

DOI:10.1002/ana.410250304
PMID:2729913
Abstract

In more than 50% of amaurosis fugax patients under 45 years of age no cause for the episodes of visual loss is identifiable. We have encountered 6 young adults (4 women and 2 men) with episodes of amaurosis fugax associated with elevated levels of antiphospholipid antibodies. Splinter hemorrhages of the nail beds were present in most patients. Treatment with antiplatelet medications and anticoagulants appeared to reduce the frequency of episodes and might prevent central retinal artery occlusions or stroke.

摘要

在45岁以下的一过性黑矇患者中,超过50%的患者无法确定视力丧失发作的原因。我们遇到过6例年轻成人(4名女性和2名男性),其一过性黑矇发作与抗磷脂抗体水平升高有关。大多数患者存在甲床裂片样出血。使用抗血小板药物和抗凝剂治疗似乎可降低发作频率,并可能预防视网膜中央动脉阻塞或中风。

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Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?短暂性单眼视力丧失(一过性黑矇):年龄如何影响诊断?
Ophthalmol Ther. 2024 Jun;13(6):1417-1425. doi: 10.1007/s40123-024-00932-z. Epub 2024 Apr 8.
2
Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overview.抗磷脂综合征与血管性缺血(闭塞性)疾病:综述
Yonsei Med J. 2007 Dec 31;48(6):901-26. doi: 10.3349/ymj.2007.48.6.901.
3
Retinal, ophthalmic, or ocular migraine.视网膜性、眼科性或眼性偏头痛。
Curr Neurol Neurosci Rep. 2004 Sep;4(5):391-7. doi: 10.1007/s11910-004-0086-5.
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Unusual manifestations of the antiphospholipid syndrome.抗磷脂综合征的不寻常表现。
Clin Rev Allergy Immunol. 2003 Aug;25(1):61-78. doi: 10.1385/CRIAI:25:1:61.
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Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model.抗磷脂抗体相关的神经功能障碍和多动行为。一种小鼠模型。
J Clin Invest. 1997 Aug 1;100(3):613-9. doi: 10.1172/JCI119572.
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Antiphospholipid antibodies syndrome and cerebral ischemia.抗磷脂抗体综合征与脑缺血
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Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options.原发性抗磷脂抗体综合征与脑缺血:两例急性干预报告及侧重于治疗选择的文献综述
Rheumatol Int. 1993;13(4):169-74. doi: 10.1007/BF00301266.
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Controversies in lupus: nervous system involvement.狼疮的争议:神经系统受累
Ann Rheum Dis. 1995 Mar;54(3):159-67. doi: 10.1136/ard.54.3.159.
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Subungual splinter haemorrhages: a new sign of the antiphospholipid coagulopathy?甲下线状出血:抗磷脂凝血障碍的新体征?
Ann Rheum Dis. 1990 Apr;49(4):268. doi: 10.1136/ard.49.4.268-a.