抗寄生虫药物硝呋替莫和苯硝唑的抗菌活性。
Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole.
作者信息
Hof H
机构信息
Institute of Medical Microbiology and Hygiene, University of Heidelberg, Faculty of Clinical Medicine Mannheim, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1989 Mar;33(3):404-5. doi: 10.1128/AAC.33.3.404.
Abstract
Both nifurtimox and benznidazole, which are used for the treatment of Chagas' disease, also display marked antibacterial activities. Characteristically for nitroheterocyclic compounds, they are much more active against anaerobic and microaerophilic bacteria than against aerobic bacteria. Nitroreductase-deficient aerobes are completely resistant, whereas SOS-repair-deficient strains are moderately susceptible. Those strains are rapidly killed.
摘要
用于治疗恰加斯病的硝呋替莫和苯硝唑也显示出显著的抗菌活性。作为硝基杂环化合物的特性，它们对厌氧菌和微需氧菌的活性比对需氧菌的活性要强得多。缺乏硝基还原酶的需氧菌完全耐药，而缺乏SOS修复的菌株则中度敏感。这些菌株会被迅速杀死。
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