顺铂在体内的全身递送与生物分布
Systemic Delivery and Biodistribution of Cisplatin in Vivo.
作者信息
Chu Yu-Hsuan, Sibrian-Vazquez Martha, Escobedo Jorge O, Phillips Amanda R, Dickey D Thomas, Wang Qi, Ralle Martina, Steyger Peter S, Strongin Robert M
机构信息
Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
出版信息
Mol Pharm. 2016 Aug 1;13(8):2677-82. doi: 10.1021/acs.molpharmaceut.6b00240. Epub 2016 Jun 24.
Abstract
Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.
摘要
顺铂被广泛用于治疗多种癌症。然而，耳毒性和肾毒性仍然是基于顺铂化疗的严重副作用。为了为顺铂脱靶效应的研究提供信息，合成了一种新的药物-荧光团共轭物，该共轭物可作为示踪剂来确定顺铂的细胞摄取和体内分布。该探针将作为一种有用的工具，有助于在临床前模型中全身给药后研究顺铂的动力学、生物分布及其相关副作用。
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本文引用的文献
1
Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors.
Onco Targets Ther. 2016 May 10;9:2769-81. doi: 10.2147/OTT.S99242. eCollection 2016.
2
Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.
Sci Transl Med. 2015 Jul 29;7(298):298ra118. doi: 10.1126/scitranslmed.aac5546.
3
Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds.
PLoS One. 2013 Jun 3;8(6):e66220. doi: 10.1371/journal.pone.0066220. Print 2013.
4
Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.
J Neurosci. 2013 Mar 6;33(10):4405-14. doi: 10.1523/JNEUROSCI.3940-12.2013.
5
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.
Sci Rep. 2011;1:159. doi: 10.1038/srep00159. Epub 2011 Nov 16.
6
Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy.
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12435-40. doi: 10.1073/pnas.1007026107. Epub 2010 Jun 23.
7
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.
Am J Pathol. 2010 Mar;176(3):1169-80. doi: 10.2353/ajpath.2010.090610. Epub 2010 Jan 28.
8
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
J Assoc Res Otolaryngol. 2009 Jun;10(2):205-19. doi: 10.1007/s10162-009-0160-4. Epub 2009 Mar 3.
9
Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death.
PLoS Genet. 2008 Feb 29;4(2):e1000020. doi: 10.1371/journal.pgen.1000020.
10
A systemic gentamicin pathway across the stria vascularis.
Hear Res. 2008 Jan;235(1-2):114-24. doi: 10.1016/j.heares.2007.10.010. Epub 2007 Nov 17.
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