Bogen Sarah, Legenbauer Tanja, Gest Stephanie, Holtmann Martin
1 Ruhr Universität Bochum, LWL Universitätsklinik Hamm.
Z Kinder Jugendpsychiatr Psychother. 2017 Jan;45(1):34-41. doi: 10.1024/1422-4917/a000442. Epub 2016 Jun 13.
In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients.
This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later.
No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores.
The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.
近年来，强光疗法（BLT）已被用于治疗抑郁症并稳定昼夜节律。在本研究中，我们评估了其对抑郁住院患者情感和行为失调的共病症状是否也有帮助。
本文报告了一项二次分析，比较了两组患有情感和行为失调共病的抑郁参与者，通过优势与困难问卷失调量表（SDQ-DP）进行评估（n = 16 vs. n = 11）。参与者被随机分配到活性BLT（10000勒克斯）或对照BLT（约100勒克斯）组，并接受为期2周、每次45分钟的BLT治疗。在基线、干预后及3周后评估SDQ-DP评分、睡眠参数和昼夜偏好。
未观察到对SDQ-DP评分的直接影响。两种情况下睡眠均有改善。仅在活性BLT组中发现昼夜节律提前。相关性和回归分析表明，SDQ-DP评分改善存在间接的昼夜节律效应。
该初步试验的数据应被视为初步的且仅具有描述性。有必要进行进一步研究。
