Department of Haematology and Transfusiology, National Centre of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Department of Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Semin Thromb Hemost. 2017 Feb;43(1):8-13. doi: 10.1055/s-0036-1584352. Epub 2016 Jun 14.
The knowledge on the etiology of thrombosis has increased tremendously over the past decades. Nevertheless, Virchow triad is still traditionally invoked to explain mechanisms leading to thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall components, and blood flow in the development of arterial and venous thrombosis. Recent decades have been focused primarily on describing abnormalities in blood composition, including defects of coagulation proteins and platelets. Although defects of coagulation factors are relatively well-described in the literature, prothrombotic platelet disorders are still less understood. One such defect, the Wien-Penzing defect was first described in 1991. Another platelet defect is sticky platelet syndrome (SPS). In this article, we review information about SPS, and we propose a new definition and standardization of diagnostic criteria. We also attempt to explain the causes and consequences of this condition.
在过去的几十年里，人们对血栓形成的病因有了极大的了解。尽管如此，传统上仍然援引Virchow 三联征来解释导致血栓形成的机制，即血液成分、血管壁成分和血流的异常协同作用导致动脉和静脉血栓形成。近几十年来，主要集中在描述血液成分的异常，包括凝血蛋白和血小板的缺陷。虽然凝血因子的缺陷在文献中已有较为详细的描述，但促血栓形成的血小板异常仍了解较少。其中一个缺陷是 Wien-Penzing 缺陷，该缺陷于 1991 年首次被描述。另一个血小板缺陷是粘性血小板综合征（SPS）。在本文中，我们回顾了有关 SPS 的信息，并提出了一个新的定义和诊断标准的标准化。我们还试图解释这种情况的原因和后果。
