Oleskin A V, El'-registan G I, Shenderov B A
Mikrobiologiia. 2016 Jan-Feb;85(1):3-25.
Current concepts concerning social behavior of the microorganisms inhabiting human gastrointestinal tract, as well as their role in the formation of integrated supracellular structures and in intercellular communication in the host-microbiota system are reviewed. Analysis of the literature data and the results obtained by the authors indicate an important role of neuromediators (biogenic amines, amino acids, peptides, and nitric oxide) in the intra- and interspecies microbial communication, as well as in the microbiota-host dialogue. The role of this dialogue for human health, its effect on human psyche and social behavior, and the possibility of construction of probiotic preparations with a goal-directed neurochemical effect are discussed.
本文综述了有关人类胃肠道微生物群落社会行为的当前概念，以及它们在宿主 - 微生物群系统中整合超细胞结构形成和细胞间通讯中的作用。对文献数据和作者所得结果的分析表明，神经介质（生物胺、氨基酸、肽和一氧化氮）在种内和种间微生物通讯以及微生物群与宿主对话中具有重要作用。本文还讨论了这种对话对人类健康的作用、其对人类心理和社会行为的影响，以及构建具有定向神经化学效应的益生菌制剂的可能性。
