Affiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nutrilite Health Institute, Shanghai, China.
Front Cell Infect Microbiol. 2022 Aug 26;12:932309. doi: 10.3389/fcimb.2022.932309. eCollection 2022.
Perinatal depression is a mood disorder that is reported in women during pregnancy (prenatal) and after childbirth (postnatal). The onset of perinatal depression is associated with changes in reproductive hormones, stress hormones and neurosteroids. These chemical compounds can be modulated by the gut microbiota, which may affect maternal mental health during the perinatal period the gut-brain-axis. Recent studies suggest that nutritional and dietary interventions (vitamin D, ω-3 fatty acids, iron, and fiber) effectively prevent or mitigate maternal depression and anxiety, but their efficacy is confounded by various factors, including the gut microbiota. Probiotics are efficacious in maintaining microbiota homeostasis, and thus, have the potential to modulate the development of perinatal mood disorders, despite no evidence in human. Therefore, clinical trials are warranted to investigate the role of probiotic supplementation in perinatal depression and behavioral changes. This article reviews the interplay between nutrition, gut microbiota and mood and cognition, and the evidence suggesting that probiotics affect the onset and development of perinatal depression.
围产期抑郁症是一种在女性怀孕期间（产前）和分娩后（产后）报告的情绪障碍。围产期抑郁症的发病与生殖激素、应激激素和神经甾体的变化有关。这些化学物质可以被肠道微生物群调节，这可能会影响围产期的产妇心理健康——肠道-大脑轴。最近的研究表明，营养和饮食干预（维生素 D、ω-3 脂肪酸、铁和纤维）可以有效预防或减轻产妇的抑郁和焦虑，但它们的疗效受到各种因素的影响，包括肠道微生物群。益生菌在维持微生物群平衡方面是有效的，因此，尽管在人类中没有证据，但它们有可能调节围产期情绪障碍的发展。因此，有必要进行临床试验来研究益生菌补充在围产期抑郁和行为变化中的作用。本文综述了营养、肠道微生物群和情绪与认知之间的相互作用，以及益生菌可能影响围产期抑郁发病和发展的证据。
