• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Structure-activity relationships for the direct toxic action of trichothecenes on rat brain.

作者信息

Bergmann F, Yagen B

机构信息

Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

出版信息

Arch Toxicol. 1989;63(2):155-6. doi: 10.1007/BF00316439.

DOI:10.1007/BF00316439
PMID:2730341
Abstract

Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3 alpha-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8 alpha-hydroxy group enhances toxicity about 4-fold.

摘要

相似文献

1
Structure-activity relationships for the direct toxic action of trichothecenes on rat brain.
Arch Toxicol. 1989;63(2):155-6. doi: 10.1007/BF00316439.
2
Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats.
Toxicol Lett. 1989 Jul;48(1):49-56. doi: 10.1016/0378-4274(89)90185-9.
3
Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks.12,13-环氧单端孢霉烯族毒素对1日龄肉仔鸡的急性毒性
Appl Environ Microbiol. 1978 Apr;35(4):636-40. doi: 10.1128/aem.35.4.636-640.1978.
4
Systemic effects of topically applied trichothecenes. I. Comparative study of various trichothecenes in mice.局部应用单端孢霉烯族毒素的全身效应。I. 小鼠体内各种单端孢霉烯族毒素的比较研究。
Zentralbl Veterinarmed A. 1986 Jul;33(5):373-83. doi: 10.1111/j.1439-0442.1986.tb00546.x.
5
Systemic effects of topical application of trichothecenes in rodents.单端孢霉烯族毒素在啮齿动物中的局部应用的全身效应。
Arch Belg. 1984;Suppl:223-5.
6
Cerebral toxicity of the trichothecene toxin T-2, of the products of its hydrolysis and of some related toxins.单端孢霉烯族毒素T-2、其水解产物及某些相关毒素的脑毒性。
Toxicon. 1988;26(10):923-30. doi: 10.1016/0041-0101(88)90257-7.
7
Trichothecenes: structure-toxic activity relationships. trichothecenes：结构-毒性活性关系。
Curr Drug Metab. 2013 Jul;14(6):641-60. doi: 10.2174/1389200211314060002.
8
Challenges and pitfalls in experimental studies with trichothecene mycotoxins.
Dev Toxicol Environ Sci. 1986;12:283-90.
9
Toxicology of novel macrocyclic trichothecenes, baccharinoid B4, myrotoxin B, and roritoxin B.
Zentralbl Veterinarmed A. 1989 Feb;36(2):152-60. doi: 10.1111/j.1439-0442.1989.tb00715.x.
10
The toxicity of macrocyclic trichothecenes administered directly into the rat brain.直接注入大鼠脑内的大环单端孢霉烯族毒素的毒性。
Toxicon. 1992 Oct;30(10):1291-4. doi: 10.1016/0041-0101(92)90444-a.

本文引用的文献

1
Chemical interconversion of T-2 and HT-2 toxins and related compounds.T-2毒素和HT-2毒素及相关化合物的化学相互转化
Biochem Biophys Res Commun. 1971 Oct 15;45(2):396-401. doi: 10.1016/0006-291x(71)90832-1.
2
Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle.与奶牛致命性中毒相关的霉变玉米中T-2毒素的鉴定。
Appl Microbiol. 1972 Nov;24(5):684-90. doi: 10.1128/am.24.5.684-690.1972.
3
Macrocyclic trichothecenes: cause of livestock poisoning by the Brazilian plant Baccharis coridifolia.
大环单端孢霉烯族毒素：巴西植物心叶酒神菊导致家畜中毒的原因。
Toxicon. 1985;23(5):731-45. doi: 10.1016/0041-0101(85)90003-0.
4
Toxic and lethal effects of T-2 toxin upon intracerebral administration to rats.
Arch Toxicol. 1985 Oct;58(1):40-4. doi: 10.1007/BF00292615.
5
Structure-function relationships of 12,13-epoxytrichothecene mycotoxins in cell culture: comparison to whole animal lethality.12,13-环氧单端孢霉烯族霉菌毒素在细胞培养中的结构-功能关系：与整体动物致死率的比较
Toxicon. 1986;24(10):985-94. doi: 10.1016/0041-0101(86)90004-8.
6
Cerebral toxicity of the trichothecene toxin T-2, of the products of its hydrolysis and of some related toxins.单端孢霉烯族毒素T-2、其水解产物及某些相关毒素的脑毒性。
Toxicon. 1988;26(10):923-30. doi: 10.1016/0041-0101(88)90257-7.
7
The larvicidal activity of some 12,13-epoxytrichothec-9-enes.
Biochem Pharmacol. 1975 May 1;24(9):959-62. doi: 10.1016/0006-2952(75)90427-x.
8
Metabolism of trichothecene mycotoxins. II. Substrate specificity of microsomal deacetylation of trichothecenes.单端孢霉烯族霉菌毒素的代谢。II. 单端孢霉烯族霉菌毒素微粒体脱乙酰作用的底物特异性。
J Biochem. 1978 Sep;84(3):697-706. doi: 10.1093/oxfordjournals.jbchem.a132175.