Davami Mohammad Hasan, Baharlou Rasoul, Ahmadi Vasmehjani Abbas, Ghanizadeh Ahmad, Keshtkar Mitra, Dezhkam Iman, Atashzar Mohammad Reza
Department of Immunology and Microbiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Basic Clin Neurosci. 2016 Apr;7(2):137-42. doi: 10.15412/J.BCN.03070207.
Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls.
Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA.
The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/mL (P>0.05).
Considering pro-inflammatory cytokines, current results support the association of inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.
抑郁症是一种与免疫系统高度相关的精神障碍。因此，本研究比较了重度抑郁症患者与健康对照者血清中白细胞介素-21（IL-21）、白细胞介素-17（IL-17）和转化生长因子β（TGF-β）的浓度。
采集41例重度抑郁症患者和40例年龄匹配、无恶性肿瘤或自身免疫性疾病病史的健康对照者的血样。根据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断标准对受试者进行面对面访谈。两组均使用贝克抑郁量表完整版测量抑郁得分。采用酶联免疫吸附测定法（ELISA）评估血清中IL-21、IL-17和TGF-β的浓度。
患者组和对照组的贝克抑郁量表平均得分分别为35.4±5.5和11.1±2.3。患者组和对照组的IL-17血清浓度分别为10.03±0.6和7.6±0.6 pg/mL（P = 0.0002）。患者组的TGF-β水平显著高于对照组；分别为336.7±20.19和174.8±27.20 pg/mL（P < 0.0001）。然而，两组之间的IL-21水平无统计学差异，分别为84.30±4.57和84.12±4.15 pg/mL（P > 0.05）。
考虑到促炎细胞因子，目前的结果支持炎症反应与抑郁症之间的关联。因此，促炎因子谱似乎可作为抑郁症进展及治疗效果监测的指标。
