NMDA受体的非离子型信号传导：争议与机遇
Non-ionotropic signaling by the NMDA receptor: controversy and opportunity.
作者信息
Gray John A, Zito Karen, Hell Johannes W
机构信息
Center for Neuroscience, University of California, Davis, CA, USA; Department of Neurology, University of California, Davis, CA, USA.
Center for Neuroscience, University of California, Davis, CA, USA; Department of Neurobiology, Physiology & Behavior, University of California, Davis, CA, USA.
出版信息
F1000Res. 2016 May 26;5. doi: 10.12688/f1000research.8366.1. eCollection 2016.
Provocative emerging evidence suggests that the N-methyl-d-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the receptor, independently of channel opening. Non-ionotropic NMDA receptor signaling has been proposed to be sufficient to induce synaptic long-term depression (LTD), directly challenging the decades-old model that prolonged low-level calcium influx is required to induce LTD. Here, we briefly review these recent findings, focusing primarily on the potential role of non-ionotropic signaling in NMDA receptor-mediated LTD. Further reports concerning additional roles of non-ionotropic NMDA receptor signaling are also discussed. If validated, this new view of NMDA receptor-mediated signaling will usher in an exciting new era of exploring synapse function and dysfunction.
引人关注的新证据表明，N-甲基-D-天冬氨酸（NMDA）受体在没有离子通过受体流动的情况下也能发出信号。这种非离子型信号传导被认为是由于激动剂诱导受体构象发生变化，而与通道开放无关。有人提出非离子型NMDA受体信号传导足以诱导突触长时程抑制（LTD），这直接挑战了数十年来认为诱导LTD需要长时间低水平钙内流的模型。在此，我们简要回顾这些最新发现，主要关注非离子型信号传导在NMDA受体介导的LTD中的潜在作用。还讨论了有关非离子型NMDA受体信号传导其他作用更多的报告。如果得到验证，这种NMDA受体介导信号传导的新观点将开启探索突触功能和功能障碍的激动人心的新时代。
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