Keçecioğlu Mehmet, Tokmak Aytekin, Keçecioğlu Tuğban S, Akselim Burak, Karakaya Burcu K, Taşçı Yasemin
Ginekol Pol. 2016;87(5):390-4. doi: 10.5603/GP.2016.0010.
The effect of exogenous progesterone on fetal nuchal translucency (NT) has been proposed recently. In this study, we aimed to compare the thickness of NT of patients receiving and not receiving progesterone for threatened miscarriage.
This study was designed as a retrospective comparative study. Ninety five women treated with progesterone constituted the study group whereas 97 women who were not treated with progesterone constituted the control group. An ultrasonographic examination was performed on all of the women to measure NT. All patients were treated with oral micronized progesterone in the study group. The main parameters recorded for each woman were; age, body mass index (BMI), obstetrical characteristics, and gestational age at first examination, treatment duration of progesterone therapy, and results of combined and triple tests.
A total of 192 pregnant women with threatened miscarriage were included in this study. The mean NT thickness was statistically significantly higher in the study group (p < 0.001), and mean serum level of human chorionic gonadotropin (hCG) was also higher in this group (p < 0.05). There was no statistically significant difference between groups in terms of age, BMI, and gestational age at first examination. ROC curve analysis demonstrated that only increased NT (area under the curve: 0.634, p = 0.005, 95% CI: 0.541-0.727) was a discriminative factor for women receiving progesterone for threatened miscarriage. Also there was a positive correlation between NT and treatment duration (r = 0.269; p < 0.001).
We think that oral progesterone therapy may increase NT depending on treatment duration without causing abnormal prenatal screening test results.
近期有人提出外源性孕酮对胎儿颈部透明带（NT）的影响。在本研究中，我们旨在比较接受和未接受孕酮治疗的先兆流产患者的NT厚度。
本研究设计为回顾性比较研究。接受孕酮治疗的95名女性构成研究组，未接受孕酮治疗的97名女性构成对照组。对所有女性进行超声检查以测量NT。研究组所有患者均接受口服微粒化孕酮治疗。记录每名女性的主要参数包括：年龄、体重指数（BMI）、产科特征、首次检查时的孕周、孕酮治疗持续时间以及联合检测和三联检测结果。
本研究共纳入192例先兆流产孕妇。研究组的平均NT厚度在统计学上显著更高（p < 0.001），且该组的人绒毛膜促性腺激素（hCG）平均血清水平也更高（p < 0.05）。两组在年龄、BMI和首次检查时的孕周方面无统计学显著差异。ROC曲线分析表明，仅NT增加（曲线下面积：0.634，p = 0.005，95%可信区间：0.541 - 0.727）是接受孕酮治疗的先兆流产女性的一个判别因素。此外，NT与治疗持续时间之间存在正相关（r = 0.269；p < 0.001）。
我们认为口服孕酮治疗可能会根据治疗持续时间增加NT，而不会导致产前筛查试验结果异常。
