对血管铸型兔主动脉早期动脉粥样硬化病变的定量测量。

Quantitative measurements of early atherosclerotic lesions on rabbit aortae from vascular casts.

作者信息

Zeindler C M, Kratky R G, Roach M R

机构信息

Department of Medical Biophysics, University of Western Ontario, London, Canada.

出版信息

Atherosclerosis. 1989 Apr;76(2-3):245-55. doi: 10.1016/0021-9150(89)90108-1.

DOI:10.1016/0021-9150(89)90108-1

PMID:2730721

Abstract

We have measured the size and location of fatty atherosclerotic lesions in the cholesterol fed rabbit by scanning electron microscopic analysis of vascular casts. The aortic periorificial lesions examined in this study have been divided into proximal (upstream), distal (downstream) and lateral (to the sides of the branch). Lateral lesions developed after 1 week on diet, followed by distal lesions at 2 weeks, and occasional proximal lesions at 4 weeks. The area covered by the lesions shows a strong linear relationship (P less than 0.001) to the cross-sectional area of the branch after 2 weeks on the cholesterol diet.

摘要

我们通过对血管铸型进行扫描电子显微镜分析，测量了喂食胆固醇的兔子体内脂肪性动脉粥样硬化病变的大小和位置。本研究中检查的主动脉口周病变分为近端（上游）、远端（下游）和外侧（分支两侧）病变。外侧病变在饮食1周后出现，随后2周出现远端病变，4周时偶尔出现近端病变。在胆固醇饮食2周后，病变覆盖面积与分支横截面积呈强线性关系（P小于0.001）。