Schäfer Christian, Ragazzon Giulio, Colasson Benoit, La Rosa Marcello, Silvi Serena, Credi Alberto
Photochemical Nanosciences Laboratory Dipartimento di Chimica "G. Ciamician" Alma Mater Studiorum-Università di Bologna via Selmi 2 40126 Bologna Italy.
ChemistryOpen. 2015 Dec 30;5(2):120-4. doi: 10.1002/open.201500217. eCollection 2016 Apr.
The transport of substrates is one of the main tasks of biomolecular machines in living organisms. We report a synthetic small-molecule system designed to catch, displace, and release molecular cargo in solution under external control. The system consists of a bistable rotaxane that behaves as an acid-base controlled molecular shuttle, whose ring component bears a tether ending with a nitrile group. The latter can be coordinated to a ruthenium complex that acts as the load, and dissociated upon irradiation with visible light. The cargo loading/unloading and ring transfer/return processes are reversible and can be controlled independently. The robust coordination bond ensures that the cargo remains attached to the device while the transport takes place.
底物的运输是生物体内生物分子机器的主要任务之一。我们报道了一种合成小分子系统，该系统设计用于在外部控制下在溶液中捕获、置换和释放分子货物。该系统由一个双稳态轮烷组成，它作为一个酸碱控制的分子穿梭体，其环组件带有一个以腈基结尾的系链。后者可以与作为负载的钌配合物配位，并在可见光照射下解离。货物的装载/卸载和环转移/返回过程是可逆的，并且可以独立控制。强大的配位键确保在运输过程中货物保持附着在装置上。
