Xu Xiaojie, Ye Qinong
Department of Medical Molecular Biology; Beijing Institute of Biotechnology; Beijing, PR China.
Mol Cell Oncol. 2014 Sep 2;1(1):e29910. doi: 10.4161/mco.29910. eCollection 2014.
Viral infection may play a causative role in human cancers, for example hepatitis B virus (HBV) or hepatitis C virus (HCV) in liver cancer, human papilloma virus (HPV) in cervical cancer, and Epstein-Barr virus (EBV) in nasopharyngeal carcinoma. Virally infected cells express viral-encoded genes that are critical for oncogenesis. Some viruses also encode microRNA (miRNA) species. miRNAs are small noncoding RNA molecules that play an important role in cancer development and progression. Recent studies indicate an important interplay among viral oncoproteins, virus-encoded miRNAs, cellular miRNAs, and cellular genes. This review focuses on modulation of HBV-, HCV-, HPV-, and EBV-associated cancers by cellular and/or viral miRNA. An understanding of the mechanisms underlying the regulation of viral carcinogenesis by miRNAs may provide new targets for the development of specific viral therapies.
病毒感染可能在人类癌症中起致病作用，例如肝癌中的乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）、宫颈癌中的人乳头瘤病毒（HPV）以及鼻咽癌中的爱泼斯坦 - 巴尔病毒（EBV）。病毒感染的细胞表达对肿瘤发生至关重要的病毒编码基因。一些病毒还编码微小RNA（miRNA）。miRNA是小的非编码RNA分子，在癌症发展和进展中起重要作用。最近的研究表明病毒癌蛋白、病毒编码的miRNA、细胞miRNA和细胞基因之间存在重要的相互作用。本综述重点关注细胞和/或病毒miRNA对HBV、HCV、HPV和EBV相关癌症的调节作用。了解miRNA调节病毒致癌作用的机制可能为开发特异性病毒疗法提供新的靶点。
