• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内质网可能是经历了上皮-间质转化的癌细胞的致命弱点。

The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition.

作者信息

Feng Yu-Xiong, Sokol Ethan S, Gupta Piyush B

机构信息

Whitehead Institute for Biomedical Research , 9 Cambridge Center ; Cambridge, MA USA.

Whitehead Institute for Biomedical Research, 9 Cambridge Center; Cambridge, MA USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.

出版信息

Mol Cell Oncol. 2014 Oct 29;1(2):e961822. doi: 10.4161/23723548.2014.961822. eCollection 2014 Apr-Jun.

DOI:10.4161/23723548.2014.961822
PMID:27308337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4905182/
Abstract

In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings.

摘要

在最近发表于《癌症发现》的一份报告中，我们发现了经历上皮-间质转化（EMT）的癌细胞的一种新弱点，并证实未折叠蛋白反应的PERK分支在EMT过程中被持续激活。在这篇评论中，我们总结并阐述了我们的研究发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ca/4905182/85233946bca7/kmco-01-02-961822-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ca/4905182/85233946bca7/kmco-01-02-961822-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ca/4905182/85233946bca7/kmco-01-02-961822-g001.jpg

相似文献

1
The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition.内质网可能是经历了上皮-间质转化的癌细胞的致命弱点。
Mol Cell Oncol. 2014 Oct 29;1(2):e961822. doi: 10.4161/23723548.2014.961822. eCollection 2014 Apr-Jun.
2
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.上皮-间充质转化激活 PERK-eIF2α 并使细胞对内质网应激敏感。
Cancer Discov. 2014 Jun;4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4.
3
ATF6 pathway of unfolded protein response mediates advanced oxidation protein product-induced hypertrophy and epithelial-to-mesenchymal transition in HK-2 cells.未折叠蛋白反应的ATF6信号通路介导晚期氧化蛋白产物诱导的HK-2细胞肥大和上皮-间质转化。
Mol Cell Biochem. 2015 Sep;407(1-2):197-207. doi: 10.1007/s11010-015-2469-0. Epub 2015 Jun 5.
4
Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.铁螯合与癌症治疗领域的拓展视野：铁在调节内质网应激和上皮-间质转化中的作用
Biochim Biophys Acta. 2014 Apr;1845(2):166-81. doi: 10.1016/j.bbcan.2014.01.005. Epub 2014 Jan 25.
5
UPR: An Upstream Signal to EMT Induction in Cancer.未折叠蛋白反应：癌症中上皮-间质转化诱导的上游信号
J Clin Med. 2019 May 8;8(5):624. doi: 10.3390/jcm8050624.
6
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion.内质网相关未折叠蛋白反应在癌细胞迁移和侵袭中的新作用
Cancers (Basel). 2019 May 6;11(5):631. doi: 10.3390/cancers11050631.
7
Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis.苯丁酸可抑制博来霉素诱导的肺纤维化过程中的上皮-间质转化。
Toxicol Lett. 2015 Jan 5;232(1):213-20. doi: 10.1016/j.toxlet.2014.10.013. Epub 2014 Oct 18.
8
Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy.蛋白精氨酸甲基转移酶-1 诱导肾小管上皮细胞内质网应激和上皮-间充质转化，并促进糖尿病肾病的发生。
Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2563-2575. doi: 10.1016/j.bbadis.2019.06.001. Epub 2019 Jun 11.
9
Role of the unfolded protein response in topography-induced osteogenic differentiation in rat bone marrow mesenchymal stem cells.未折叠蛋白反应在大鼠骨髓间充质干细胞的形貌诱导成骨分化中的作用。
Acta Biomater. 2017 May;54:175-185. doi: 10.1016/j.actbio.2017.03.018. Epub 2017 Mar 14.
10
The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production.未折叠蛋白反应的 PERK 臂通过抑制蛋白翻译和促进 I 型干扰素产生来负调控传染性胃肠炎病毒复制。
J Virol. 2018 Jul 17;92(15). doi: 10.1128/JVI.00431-18. Print 2018 Aug 1.

引用本文的文献

1
Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.17β-HSD12（长链脂肪酸合成中的 3-酮酰基辅酶 A 还原酶）对乳腺癌细胞增殖和迁移的影响。
Cell Mol Life Sci. 2020 Mar;77(6):1153-1175. doi: 10.1007/s00018-019-03227-w. Epub 2019 Jul 13.
2
Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.己糖-6-磷酸脱氢酶通过对未折叠蛋白反应、钙稳态和氧化还原平衡的多效作用来控制癌细胞的增殖和迁移。
FASEB J. 2018 May;32(5):2690-2705. doi: 10.1096/fj.201700870RR. Epub 2018 Jan 2.
3

本文引用的文献

1
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.上皮-间充质转化激活 PERK-eIF2α 并使细胞对内质网应激敏感。
Cancer Discov. 2014 Jun;4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4.
2
Identification of a selective small molecule inhibitor of breast cancer stem cells.鉴定乳腺癌干细胞的选择性小分子抑制剂。
Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4. doi: 10.1016/j.bmcl.2012.01.035. Epub 2012 Jan 25.
3
The unfolded protein response: from stress pathway to homeostatic regulation.
Targeting protein quality control pathways in breast cancer.
靶向乳腺癌中的蛋白质质量控制通路。
BMC Biol. 2017 Nov 16;15(1):109. doi: 10.1186/s12915-017-0449-4.
未折叠蛋白反应：从应激途径到动态平衡调节。
Science. 2011 Nov 25;334(6059):1081-6. doi: 10.1126/science.1209038.
4
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.旁分泌和自分泌信号诱导和维持乳腺中的间充质和干细胞状态。
Cell. 2011 Jun 10;145(6):926-40. doi: 10.1016/j.cell.2011.04.029.
5
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells.SNAIL 调节人结直肠癌细胞中白细胞介素-8 的表达、干细胞样活性和致瘤性。
Gastroenterology. 2011 Jul;141(1):279-91, 291.e1-5. doi: 10.1053/j.gastro.2011.04.008. Epub 2011 Apr 16.
6
Identification of selective inhibitors of cancer stem cells by high-throughput screening.通过高通量筛选鉴定癌症干细胞的选择性抑制剂。
Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
7
The basics of epithelial-mesenchymal transition.上皮-间质转化的基础知识。
J Clin Invest. 2009 Jun;119(6):1420-8. doi: 10.1172/JCI39104.
8
The epithelial-mesenchymal transition generates cells with properties of stem cells.上皮-间质转化产生具有干细胞特性的细胞。
Cell. 2008 May 16;133(4):704-15. doi: 10.1016/j.cell.2008.03.027.
9
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines.慢性奥沙利铂耐药诱导结直肠癌细胞系发生上皮-间质转化。
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4147-53. doi: 10.1158/1078-0432.CCR-06-0038.
10
Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition.上皮-间质转化是非小细胞肺癌细胞系和异种移植对表皮生长因子受体抑制敏感性的一个决定因素。
Cancer Res. 2005 Oct 15;65(20):9455-62. doi: 10.1158/0008-5472.CAN-05-1058.