Wu Yadi, Zhou Binhua P
Department of Pharmacology and Nutrition Science; College of Medicine; University of Kentucky; Lexington, KY USA; Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA.
Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA; Department of Molecular and Cellular Biochemistry; College of Medicine; University of Kentucky; Lexington, KY USA.
Mol Cell Oncol. 2014 Dec 23;1(3):e963426. doi: 10.4161/21624011.2014.963426. eCollection 2014 Jul-Sep.
Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.
可遗传的表观遗传调控对于在不同刺激下动态控制基因表达以维持细胞内稳态和疾病进展至关重要。组蛋白甲基化是一种常见且重要的染色质修饰类型。LSD1是首个被发现的组蛋白赖氨酸特异性去甲基化酶，在发育过程和疾病状态下作为几种共抑制复合物的关键组分发挥作用。在本综述中，我们聚焦于LSD1在乳腺癌发生中的调控作用。LSD1在促进乳腺肿瘤转移和增殖以及维持乳腺癌干细胞方面发挥作用。因此，LSD1是有效治疗乳腺癌发生的一个可行治疗靶点。
