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端粒与非同源末端连接是如何共存的？

How do telomeres and NHEJ coexist?

作者信息

Marcand Stéphane

机构信息

CEA; DSV/IRCM/SIGRR/LTR; Fontenay-aux-roses; France; INSERM UMR 967; Fontenay-aux-roses; France.

出版信息

Mol Cell Oncol. 2014 Oct 29;1(3):e963438. doi: 10.4161/23723548.2014.963438. eCollection 2014 Jul-Sep.

DOI:10.4161/23723548.2014.963438
PMID:27308342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4904885/
Abstract

The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. Multiple mechanisms mediated by telomere factors act in synergy to achieve this inhibition.

摘要

真核生物的端粒是稳定的开放双链末端，与非同源末端连接（NHEJ）共存，NHEJ是一种直接连接双链断裂产生的DNA末端的修复途径。由于两个端粒之间的单个末端连接事件会产生环状染色体或不稳定的双着丝粒染色体，因此必须防止NHEJ作用于端粒。由端粒因子介导的多种机制协同作用以实现这种抑制。

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本文引用的文献

1
Role of the double-strand break repair pathway in the maintenance of genomic stability.双链断裂修复途径在维持基因组稳定性中的作用。
Mol Cell Oncol. 2014 Oct 30;2(1):e968020. doi: 10.4161/23723548.2014.968020. eCollection 2015 Jan-Mar.
2
The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres.Ku在端粒长度维持中的主要作用是促进Est1与端粒的结合。
Genetics. 2014 Aug;197(4):1123-36. doi: 10.1534/genetics.114.164707. Epub 2014 May 30.
3
Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions.从功能失调的端粒中分离染色质揭示了Ring1b在非同源末端连接介导的染色体融合中的重要作用。
Cell Rep. 2014 May 22;7(4):1320-32. doi: 10.1016/j.celrep.2014.04.002. Epub 2014 May 9.
4
DNA double-strand break repair pathway choice and cancer.DNA双链断裂修复途径的选择与癌症
DNA Repair (Amst). 2014 Jul;19:169-75. doi: 10.1016/j.dnarep.2014.03.014. Epub 2014 Apr 18.
5
Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.去磷酸化使 53BP1 募集到双链 DNA 断裂处。
Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3.
6
One ring to bring them all--the role of Ku in mammalian non-homologous end joining.一环扣一环——Ku 在哺乳动物非同源末端连接中的作用。
DNA Repair (Amst). 2014 May;17:30-8. doi: 10.1016/j.dnarep.2014.02.019. Epub 2014 Mar 26.
7
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia.21 号染色体在急性淋巴细胞白血病中的结构和体部重排。
Nature. 2014 Apr 3;508(7494):98-102. doi: 10.1038/nature13115. Epub 2014 Mar 23.
8
Elucidation of the DNA end-replication problem in Saccharomyces cerevisiae.阐明酿酒酵母 DNA 末端复制问题。
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9
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10
The spatial organization of non-homologous end joining: from bridging to end joining.非同源末端连接的空间组织：从连接桥到末端连接。
DNA Repair (Amst). 2014 May;17(100):98-109. doi: 10.1016/j.dnarep.2014.02.010. Epub 2014 Mar 11.