DNA损伤反应起始过程中涉及的分子机制。
Molecular mechanisms involved in initiation of the DNA damage response.
作者信息
Barnum Kevin J, O'Connell Matthew J
机构信息
Department of Oncological Sciences and the Graduate School of Biomedical Sciences; Icahn School of Medicine at Mount Sinai ; New York, NY USA.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(1):e970065. doi: 10.4161/23723548.2014.970065. eCollection 2015 Jan-Mar.
Abstract
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.
摘要
DNA会受到各种各样的损伤。为了维持基因组完整性，细胞必须通过激活修复和细胞周期检查点途径来应对这种损伤。DNA损伤反应中的起始事件包括损伤的识别以及在DNA处组装DNA损伤反应复合物。在此，我们综述了关于各种DNA损伤途径中这些过程的已知情况。
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