细胞质功能获得性突变型p53促成炎症相关癌症。
Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer.
作者信息
Bellazzo Arianna, Di Minin Giulio, Collavin Licio
机构信息
Laboratorio Nazionale CIB (LNCIB); AREA Science Park; Trieste, Italy; Department of Scienze della Vita; Università degli Studi di Trieste; Trieste, Italy.
Institute of Molecular Health Sciences; Swiss Federal Institute of Technology; ETH Hönggerberg ; Zurich, Switzerland.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(4):e1002719. doi: 10.1080/23723556.2014.1002719. eCollection 2015 Oct-Dec.
Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFα signaling.
肿瘤抑制因子p53的炎症和突变是两种明显不相关的情况，但它们与癌症的发生和发展密切相关。我们最近报道，功能获得性突变型p53通过结合一种参与肿瘤坏死因子α（TNFα）信号传导的细胞质肿瘤抑制蛋白，改变癌细胞对炎症信号的反应。
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