CHCHD2将线粒体代谢与细胞凋亡联系起来。
CHCHD2 connects mitochondrial metabolism to apoptosis.
作者信息
Liu Yong, Zhang Yanping
机构信息
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy; Cancer Institute; Xuzhou Medical College; Xuzhou, Jiangsu, China.
出版信息
Mol Cell Oncol. 2015 May 5;2(4):e1004964. doi: 10.1080/23723556.2015.1004964. eCollection 2015 Oct-Dec.
As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.
作为细胞的动力源和细胞凋亡的守门人，线粒体控制着生死。CHCHD2是一种先前已知可调节新陈代谢的线粒体蛋白，最近被鉴定为一种细胞凋亡抑制剂。新数据表明了一种模型，即CHCHD2通过作为活性氧清除剂和BCL-XL激活剂发挥促生存功能。
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