视黄酸受体应答蛋白3（RARRES3）通过翻译后蛋白质修饰调节信号转导。
RARRES3 regulates signal transduction through post-translational protein modifications.
作者信息
Hsu Tzu-Hui, Chang Tsu-Chung
机构信息
Genomics Research Center; Academia Sinica ; Taipei, Taiwan, ROC.
Department of Biochemistry; National Defense Medical Center ; Taipei; Taiwan, ROC.
出版信息
Mol Cell Oncol. 2015 Feb 25;2(4):e999512. doi: 10.1080/23723556.2014.999512. eCollection 2015 Oct-Dec.
Abstract
We recently reported that retinoic acid receptor responder 3 (RARRES3)-mediated protein deacylation resulted in significant inhibition of the transformed properties of breast cancer cells. This finding suggests a key role of RARRES3 in the regulation of growth signaling and metastasis in cancer cells and as a potential therapeutic target for cancer therapy.
摘要
我们最近报道，视黄酸受体反应蛋白3（RARRES3）介导的蛋白质去酰化作用可显著抑制乳腺癌细胞的转化特性。这一发现表明RARRES3在癌细胞生长信号调控和转移过程中起关键作用，并且可作为癌症治疗的潜在靶点。
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