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视黄酸受体应答蛋白3（RARRES3）通过翻译后蛋白质修饰调节信号转导。

RARRES3 regulates signal transduction through post-translational protein modifications.

作者信息

Hsu Tzu-Hui, Chang Tsu-Chung

机构信息

Genomics Research Center; Academia Sinica ; Taipei, Taiwan, ROC.

Department of Biochemistry; National Defense Medical Center ; Taipei; Taiwan, ROC.

出版信息

Mol Cell Oncol. 2015 Feb 25;2(4):e999512. doi: 10.1080/23723556.2014.999512. eCollection 2015 Oct-Dec.

DOI:10.1080/23723556.2014.999512
PMID:27308522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4905368/
Abstract

We recently reported that retinoic acid receptor responder 3 (RARRES3)-mediated protein deacylation resulted in significant inhibition of the transformed properties of breast cancer cells. This finding suggests a key role of RARRES3 in the regulation of growth signaling and metastasis in cancer cells and as a potential therapeutic target for cancer therapy.

摘要

我们最近报道，视黄酸受体反应蛋白3（RARRES3）介导的蛋白质去酰化作用可显著抑制乳腺癌细胞的转化特性。这一发现表明RARRES3在癌细胞生长信号调控和转移过程中起关键作用，并且可作为癌症治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bc/4905368/ee9af906c066/kmco-02-04-999512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bc/4905368/ee9af906c066/kmco-02-04-999512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bc/4905368/ee9af906c066/kmco-02-04-999512-g001.jpg

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本文引用的文献

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Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells.视黄酸受体应答蛋白3（RARRES3）参与人乳腺癌细胞中Wnt蛋白酰化和信号传导活性的调控。
Cell Death Differ. 2015 May;22(5):801-14. doi: 10.1038/cdd.2014.175. Epub 2014 Nov 7.
2
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation.视黄酸受体应答蛋白3通过调节黏附与分化抑制乳腺癌肺转移。
EMBO Mol Med. 2014 Jul;6(7):865-81. doi: 10.15252/emmm.201303675.
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Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines.
磷脂酶 A 和酰基转移酶 4/维甲酸受体应答蛋白 3 在肿瘤抑制和病原体限制的交汇点。
Front Immunol. 2023 Mar 31;14:1107239. doi: 10.3389/fimmu.2023.1107239. eCollection 2023.
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Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data.使用一种基于新途径的蛋白质组学和转录组学数据整合方法解码表皮生长因子信号传导中的细胞动力学
Front Genet. 2016 Jan 7;6:351. doi: 10.3389/fgene.2015.00351. eCollection 2015.
RIG1 这一 II 类肿瘤抑制基因的表达受到肿瘤抑制因子 p53 的直接调控，这一现象存在于肿瘤细胞系中。
FEBS Lett. 2012 May 7;586(9):1287-93. doi: 10.1016/j.febslet.2012.03.020. Epub 2012 Mar 27.
4
Regulating the regulator: post-translational modification of RAS.调节蛋白的调节作用：RAS 的翻译后修饰。
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