泛素特异性蛋白酶24参与DNA损伤反应。
Involvement of USP24 in the DNA damage response.
作者信息
Zhang Ling, Gong Feng
机构信息
Department of Biochemistry and Molecular Biology; University of Miami Miller School of Medicine ; Miami, FL USA.
出版信息
Mol Cell Oncol. 2015 Feb 3;3(1):e1011888. doi: 10.1080/23723556.2015.1011888. eCollection 2016 Jan.
Abstract
Deubiquitination has emerged as an important mechanism of regulating DNA repair pathways. We recently reported that USP24 is a novel p53 deubiquitinase that stabilizes p53 upon DNA damage. USP24 is upregulated by DNA damaging agents and plays an important role in maintaining genome stability.
摘要
去泛素化已成为调节DNA修复途径的一种重要机制。我们最近报道，USP24是一种新型的p53去泛素酶，在DNA损伤时可稳定p53。USP24被DNA损伤剂上调，并在维持基因组稳定性中发挥重要作用。
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本文引用的文献
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